Dangerous universal donors: the reality of the Hemocentro in Belo Horizonte, Minas Gerais

Godin, Mariana Martins; Souza, Lucas de Oliveira; Schmidt, Luciana Cayres; Vieira, Lauro Mello; Diniz, Rejane Silva; Dusse, Luci Maria Sant’Ana

doi:10.1016/j.bjhh.2016.05.007

Cited by 7 publications

(3 citation statements)

References 18 publications

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“…In the present study significant association between high titer and age was observed. There are few publications that have described a relationship between titer and age 10,11 mostly pointing out higher prevalence among young age group. Study by Rachel beddard at al showed a positive correlation between donor age and high titre of antibody.…”

Section: Discussionmentioning

confidence: 99%

Role of antibody screening in high titre group O donors

Shah¹,

Prajapati²,

Patel³

et al. 2023

JDPO

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Red Cells, Fresh Frozen Plasma (FFP) and Platelets (RDP/SDP) prepared from donors with group O may have high titers of anti-A, anti-B and/or anti-A,B antibodies. When such components given to non-group O patients, this high titre can result in haemolytic transfusion reactions (HTRs). Such group O donors are generally termed ‘high-titer group O donors. Significant amounts of ABO antigen being present on the platelet surface and anti-ABO iso-agglutinins being present in the donor’s plasma, Platelet transfusions need to take into account the issues. Although relatively rare, but acute intravascular haemolytic transfusion reaction has been caused by passive transfer of anti-A and anti-B antibodies, present in group O donors. This study aimed to identify the prevalence of high titre antibodies in group O donors. Thus, titre are performed in randomly selected group O donors from different gender and age group to identify best available source of products for Platelet and follow up transfusions.: Randomly selected 100 O blood group donors were included in the study. Samples from these donors were tested for ABO antibody (both IgM and IgG) titres using conventional tube technique at RT and 37°C at Indirect Antiglobulin phase. Statistical analysis was performed using two sample t-test and anova test.Donors included in the present study were mainly male (85%) donors. ABO antibody titres ranged from 0 to 2048. In the present study, Anti-B (IgG) titer is significantly higher than other antibodies in both genders. There are a large proportion of group O donors having high titres of antibodies and hence a routine pretransfusion screening for such antibodies can prevent the development of hemolytic transfusion reaction by issuing only low titre components for out of group transfusions. Each Blood Transfusion Service should establish a policy for testing and issue of group O platelets to non-O group recipient to avoid chances of development of adverse transfusion reaction.

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Section: Discussionmentioning

confidence: 99%

Role of antibody screening in high titre group O donors

Shah¹,

Prajapati²,

Patel³

et al. 2023

JDPO

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“…In general, there were more females than males with higher antibody titer levels, with significantly more females than males with anti-A, which may be caused by sensitization during pregnancies. 13,16,22 . High titers of anti-A haemolysins were reported to be associated with females 16 .…”

Section: Discussionmentioning

confidence: 99%

Determination of ABO antibody titre and haemolysin test of group O whole blood used for exchanged transfusion in a teaching hospital

Noor

Hasan

Iberahim

et al. 2022

Bangladesh J Med Sci

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Background: Group O blood donor is more readily available and is frequently used as a universal red cell donor and emergency O whole blood (EM O) for exchange transfusion in neonates. Sera from group O donors contains two separable haemolysin antibodies, anti-A and anti-B, and a cross-reacting antibody called anti-A, B (mostly IgG). The presence of haemolysins in the donors may lead to haemolysis in the recipients. Objectives: This study aims to determine the prevalence of anti-A and anti B haemolysins and titer among group O donors that we screened for emergency group O (EM O) whole blood Methodology: A cross sectional study was done to determine the prevalence of anti-A and anti B haemolysin and titer among group O blood donors screened for EM O whole blood for exchange transfusion in neonates at a teaching hospital from January to December 2018. Samples of 350 voluntary group O regular donors were selected for ABO antibodies titration and haemolysin test using the conventional tube technique at room temperature. Donors were screened for titer of 1:50 and 1:100 only. ABO antibody titer of ≥1:100 was considered as a high titer and not suitable for exchange transfusion. Titer of ≤1:50 were labeled as EM O whole blood and will be suitable for exchange transfusion. Results: A total of 350 group O blood donors were screened for the anti A and anti B haemolysin and titer. The majority of blood group O donors were male (n=215, 61%) and were age from 18-30 years old (51%). Malay was the predominant group (83%). About 52.9% of the donors were low titer (≤1:50), and 47.1% were high titer (≥1:100). Low titer was seen predominantly among male donors (61.8%). The prevalence of haemolysins in group O donors was 5.4% (n=19). Anti A and anti B haemolysins were seen in 0.57% and 2.28% of the donors, respectively, while donors having both A and B haemolysins in their sera was 2.57%. Conclusion: Prevalence of anti-A and anti-B haemolysins were low among group O blood donors. However, a significant percentage of group O donors have high titer of anti-A or anti-B. Therefore, despite the labour intensiveness of haemolysis titration technique and the frequent transfusion of group O blood for exchange transfusion, there is the need to routinely screen our donors for haemolysins in order to identify those posing the greatest risk to recipients. Bangladesh Journal of Medical Science Vol. 21 No. 02 April’22 Page : 368-372

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“…These findings are comparable with high-titer cases in Brazilian (30%) and Italian (27%) studies. 37,38 Our study was an in vitro investigation that, for the first time, showed the most frequently encountered titers of ABO antibodies in Iranian donors and compared titer values in male and female donors as well as within age ranges of these donors. We note that a clinical study is also required to determine potentially clinically critical titers in practice.…”

Section: Number Of Casesmentioning

confidence: 99%

Group O blood donors in Iran: evaluation of isoagglutinin titers and immunoglobulin G subclasses

et al. 2021

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This study aims to determine the most frequent titers of anti-A and anti-B (both presumed immunoglobulin [Ig]M and IgG) in Iranian group O blood donors and to compare these titer values with those found in other studies. In addition, alloantibody production and plasma levels of four IgG subclasses were compared between the high-titer and non-high-titer study groups. This study investigated anti-A and anti-B titers in 358 plasma samples. Based on these results, two study groups (hightiter and non-high-titer) were formed. Antibody detection tests were performed to detect unexpected antibodies to

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Dangerous universal donors: the reality of the Hemocentro in Belo Horizonte, Minas Gerais

Cited by 7 publications

References 18 publications

Role of antibody screening in high titre group O donors

Role of antibody screening in high titre group O donors

Determination of ABO antibody titre and haemolysin test of group O whole blood used for exchanged transfusion in a teaching hospital

Group O blood donors in Iran: evaluation of isoagglutinin titers and immunoglobulin G subclasses

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