Danggui Jixueteng decoction for the treatment of myelosuppression after chemotherapy: A combined metabolomics and network pharmacology analysis

Pharmacological Components and Mechanism Research on the Treatment of Myelosuppression after Chemotherapy with Danggui Jixueteng Decoction Based on Spectrum-Effect Relationships and Transcriptome Sequencing

“…The improvement of Salviae Radix on side effects induced by chemotherapy has been validated by Cho et al., while Peng et al revealed the therapeutic effect of Spatholobi caulis on bone marrow suppression . In addition, the tonifying qi and blood nourishing effects of Angelica sinensis have been repeatedly studied. , In this preliminary study, we constructed a rat model to verify the therapeutic effect of DJD on MAC and explored the core targets, key compounds, major biological processes, and signaling pathway related to treatment using network pharmacology, molecular docking, and metabolomics . However, as a TCM compound preparation, the chemical composition of DJD is complex and diverse, and the database-based prediction results do not fully represent the actual situation.…”

“… 9 , 10 In this preliminary study, we constructed a rat model to verify the therapeutic effect of DJD on MAC and explored the core targets, key compounds, major biological processes, and signaling pathway related to treatment using network pharmacology, molecular docking, and metabolomics. 11 However, as a TCM compound preparation, the chemical composition of DJD is complex and diverse, and the database-based prediction results do not fully represent the actual situation. Furthermore, the specific molecular mechanism of DJD in treating MAC is unknown.…”