2002
DOI: 10.1590/s0100-40422002000400015
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Danos ao DNA promovidos por ácido 5-aminolevulínico: possível associação com o desenvolvimento de carcinoma hepatocelular em portadores de porfiria aguda intermitente

Abstract: Recebido em 26/6/01; aceito em 1/10/01 DNA DAMAGE INDUCED BY 5-AMINOLEVULINIC ACID: A POSSIBLE ASSOCIATION WITH THE DEVELOPMENT OF HEPATOCELLULAR CARCINOMA IN ACUTE INTERMITTENT PORPHYRIA PATIENTS. 5-Aminolevulinic acid (ALA) is a heme precursor accumulated in acute intermittent porphyria (AIP), which might be associated with hepatocellular carcinoma (HCC) in symptomatic patients. Under metal catalyzed oxidation, ALA and its cyclic dimerization product, 3,6-dihydropyrazine-2,5-dipropanoic acid, produce reactiv… Show more

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Cited by 10 publications
(12 citation statements)
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References 186 publications
(269 reference statements)
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“…The strongest hypothesis to explain the association between ALA accumulation and AIP symptoms is the pro‐oxidant property of ALA and its derivatives [2, 18–22, 28]. ALA, in a basic pH, enolyzes, and in the presence of metal ions, suffers an oxidation, generating ROS and the aldehyde 4,5‐dioxovaleric acid (DOVA), as a final product [29].…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…The strongest hypothesis to explain the association between ALA accumulation and AIP symptoms is the pro‐oxidant property of ALA and its derivatives [2, 18–22, 28]. ALA, in a basic pH, enolyzes, and in the presence of metal ions, suffers an oxidation, generating ROS and the aldehyde 4,5‐dioxovaleric acid (DOVA), as a final product [29].…”
Section: Discussionmentioning
confidence: 99%
“…There is no established explanation for the higher incidence of HCC in AIP patients. Several hypotheses have been proposed [13, 17]; but much evidence points to the oxidative potential of ALA as it causes DNA damage leading to mutations that could initiate a carcinogenic process [18–22].…”
Section: Introductionmentioning
confidence: 99%
“…A lesão hepática carcinogênica na hemocromatose primária hereditária ocorre essencialmente devido ao acúmulo de ferro. Já na tirosinemia a lesão ocorre devido ao acúmulo de substâncias como o fumarilacetoacetato e o ácido aminolevulínico (3,4,11) .…”
Section: Discussionunclassified
“…Nesse caso, além do depósito de ferro proporcionado pela própria fisiopatologia da doença, houve administração exógena de sulfato ferroso, levando, provavelmente, ao agravamento do depósito tecidual de ferro e, conseqüentemente, à evolução da doença (9,11,13) .…”
Section: Discussionunclassified
“…Quanto à nefrotoxicidade induzida pelo metal, estudos mostram que mesmo em indivíduos cujos valores de Pb-s são inferiores a 10 µg/dL já é possível que haja deficiência na filtração glomerular, que pode evoluir para lesões e perda de função renal com o aumento ou persistência da exposição (MUNTNER et al, 2003;WEAVER et al, 2005;ATSDR, 2019 (ONUKI et al, 2002;LAYER et al, 2010;FLORA et al, 2012).…”
Section: Exposição Ocupacional Ao Pb No Brasilunclassified