Danshen extract does not alter pharmacokinetics of docetaxel and clopidogrel, reflecting its negligible potential in P-glycoprotein- and cytochrome P4503A-mediated herb–drug interactions

Extract of Salvia miltiorrhiza (Danshen) induces Nrf2-mediated heme oxygenase-1 expression as a cytoprotective action in RAW 264.7 macrophages

“…1). This result agrees with our previous analysis of Danshen product (Lee et al, 2011a). The calculated errors for the empirical mass numbers for phenanthraquinones were less than 1 mmu as compared with their theoretical mass.…”

Biliary Excretion of Curcumin Is Mediated by Multidrug Resistance-Associated Protein 2

“…20,21) Pharmacokinetics of Curcumin in EHBR The jugular vein (for drug administration), carotid artery (for blood sampling), and bile duct of each rat were cannulated with polyethylene tubing (Natsume, Tokyo, Japan) under anesthesia at doses of 25 mg/kg and 25 mg/kg for tiletamine and zolazepam, respectively. 22,23) Cannulae were filled with heparinized saline (20 IU/mL) to prevent blood clotting.…”

Dramatic increase in hepatic and biliary curcumin exposure by modulation of its elimination pathway in rats

“…The jugular vein, carotid artery, and urinary bladder of each rat were cannulated with polyethylene tubing under the same anaesthetic conditions as described above. [21,27] After the intravenous administration of loading and maintenance doses of curcumin either without (n = 4) or with (n = 4) probenecid as described above, plasma and urine samples were collected at 0, 20, 40, 60, and 80 min, and at 0, 40, and 80 min, respectively, after starting the infusion and were stored at -80°C for subsequent use in HPLC analysis. After the infusion was stopped, the kidneys of each rat were removed, homogenized in 2 ¥ phosphate-buffered saline by using a T10 basic Ultra-Turrax Homogenizer (IKA IKA Works, Inc., SP, Brazil), and stored at -80°C until analysis.…”