Danshen mediates through estrogen receptors to activate Akt and inhibit apoptosis effect of Leu27IGF-II-induced IGF-II receptor signaling activation in cardiomyoblasts

Weng, Yueh Shan; Kuo, Wei Wen; Kuo, Chia Hua; Tzang, Bor‐Show; Tsai, Fuu Jen; Tsai, Chang Hai; Lin, James A.; Hsieh, Dennis Jine Yuan; Huang, Chih Yang

doi:10.1016/j.fct.2013.01.008

Cited by 24 publications

(23 citation statements)

References 48 publications

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“…). The phosphorylation of PI3K and Akt were reported as an important survival factor of the cells in our previous work (Fang et al, ; Li et al, ; Huang et al, ; Tsai et al, ; Weng et al, ). The downstream of phosphorylated Bad provided an anti‐apoptosis effects through the phosphorylation by Akt (Fang et al, ).…”

Section: Discussionmentioning

confidence: 90%

Anti-apoptotic effect of San Huang Shel Shin Tang cyclodextrin complex (SHSSTc) on CCl₄-induced hepatotoxicity in rats

et al. 2014

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The metabolic loading is heavier in liver especially when injured or inflammation. San Huang Shel Shin Tang (SHSST) was an old traditional herbal decoction, which composed with Rheum officinale Baill, Scutellaria baicalnsis Geprgi and Coptis chinensis Franch (1:1:2 in weight), can provide a liver protection effects. We used a beta-cyclodextrin (β-CD) drug modification method in reduce of the necessary dose of the SHSST. As the results, the FAS-FADD expressions leaded apoptosis in CCl4 intraperitoneal (IP) injection induced acute liver injury in rats. Silymarin, baicalein, SHSST, and SHSST β-CD complex (SHSSTc) pretreatments protected liver through the decreasing of the expressions of FAS-FADD and downstream caspase-3 and caspase-8. Particularly, SHSSTc (30 mg/kg day) treatment enhanced cell survival pathway activation through the PI3K, Akt and Bad phosphorylation. Compared with SHSST as well as silymarin and baicalein, SHSSTc provided a magnificent liver protection effect, especially in survival pathway activation/TUNEL-apoptotic cell reduction/serum cholesterol level suppression. All these data suggested that β-CD complex modified the SHSST and promoted the bioavailability and liver protection effects. © 2014 Wiley Periodicals, Inc. Environ Toxicol 31: 663-670, 2016.

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Section: Discussionmentioning

confidence: 90%

Anti-apoptotic effect of San Huang Shel Shin Tang cyclodextrin complex (SHSSTc) on CCl₄-induced hepatotoxicity in rats

et al. 2014

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“…Several earlier studies have shown that the increased production and accumulation of APP-CTF-␤ and A␤ can trigger the loss of neurons/cells or increase their susceptibility to a variety of toxic agents (47,48,81). The IGF-II receptor, under certain conditions, also has been shown to regulate cell viability (29,(82)(83)(84). However, the functional relationship, if any, between A␤ peptides and the IGF-II receptor in regulating cell viability remains unclear.…”

Section: Discussionmentioning

confidence: 99%

Overexpression of the Insulin-Like Growth Factor II Receptor Increases β-Amyloid Production and Affects Cell Viability

Wang

Buggia-Prévot

Zavorka

et al. 2015

Molecular and Cellular Biology

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dAmyloid ␤ (A␤) peptides originating from amyloid precursor protein (APP) in the endosomal-lysosomal compartments play a critical role in the development of Alzheimer's disease (AD), the most common type of senile dementia affecting the elderly. Since insulin-like growth factor II (IGF-II) receptors facilitate the delivery of nascent lysosomal enzymes from the trans-Golgi network to endosomes, we evaluated their role in APP metabolism and cell viability using mouse fibroblast MS cells deficient in the murine IGF-II receptor and corresponding MS9II cells overexpressing the human IGF-II receptors. Our results show that IGF-II receptor overexpression increases the protein levels of APP. This is accompanied by an increase of ␤-site APP-cleaving enzyme 1 levels and an increase of ␤-and ␥-secretase enzyme activities, leading to enhanced A␤ production. At the cellular level, IGF-II receptor overexpression causes localization of APP in perinuclear tubular structures, an increase of lipid raft components, and increased lipid raft partitioning of APP. Finally, MS9II cells are more susceptible to staurosporine-induced cytotoxicity, which can be attenuated by ␤-secretase inhibitor. Together, these results highlight the potential contribution of IGF-II receptor to AD pathology not only by regulating expression/processing of APP but also by its role in cellular vulnerability. Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by severe memory loss followed by the deterioration of higher cognitive functions. Although most cases of AD occur sporadically after the age of 60 years, a small proportion of cases correspond to the early-onset (Ͻ60 years) autosomal dominant form of the disease. To date, mutations in three genes, the amyloid precursor protein (APP) gene on chromosome 21, the presenilin 1 (PSEN1) gene on chromosome 14, and the presenilin 2 (PSEN2) gene on chromosome 1, have been identified as the cause of a large proportion of early-onset familial AD (1-3). Additionally, inheritance of the ε4 allele of the apolipoprotein E (APOE) gene on chromosome 19 increases the risk of late-onset and sporadic AD. The neuropathological features associated with AD include the presence of extracellular ␤-amyloid (A␤) peptidecontaining neuritic plaques, intracellular tau-positive neurofibrillary tangles, and the loss of synapses and neurons in defined brain regions. Several lines of in vivo evidence suggest that A␤ peptides initiate or contribute to the neuronal loss and development of AD pathology (2, 4). A␤ peptides are generated from APP, a type I transmembrane protein, which can be processed either by nonamyloidogenic ␣-secretase or amyloidogenic ␤-secretase pathways (5, 6). The ␣-secretase cleaves APP within the A␤ domain, yielding soluble APP␣ and a 10-kDa C-terminal fragment (CTF-␣), which then can be processed by ␥-secretase to generate A␤ 17-40 /A␤ 17-42 fragments. The ␤-secretase, on the other hand, cleaves APP to generate soluble APP␤ and an A␤-containing Cterminal fragment (CTF-␤), which is fu...

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“…Since the status of ER in breast cancer cells plays an important prognostic role, therapies that antagonize the ER-related signaling, such as tamoxifen, remain important adjuvant treatments after breast cancer surgery [6–8]. Recently, several organisms, such as Ganoderma lucidum and Scutellaria baicalensis , have been reported to suppress ER expression in vitro [29, 30]; while Salvia miltiorrhiza was found to activate AKT and inhibit apoptosis in cardiomyoblasts via the estrogen receptor [31]. It is well known that hormone therapies may cause adverse effects on patients, such as insomnia, hot flushes, cancer-related fatigue, and joint pain among breast cancer patients.…”

Section: Discussionmentioning

confidence: 99%

Screening to Identify Commonly Used Chinese Herbs That Affect ERBB2 and ESR1 Gene Expression Using the Human Breast Cancer MCF‐7 Cell Line

Chiu

Chang

et al. 2014

Evidence-Based Complementary and Alternative Medicine

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Aim. Our aim the was to screen the commonly used Chinese herbs in order to detect changes in ERBB2 and ESR1 gene expression using MCF-7 cells. Methods. Using the MCF-7 human breast cancer cell line, cell cytotoxicity and proliferation were evaluated by MTT and trypan blue exclusion assays, respectively. A luciferase reporter assay was established by transient transfecting MCF-7 cells with plasmids containing either the ERBB2 or the ESR1 promoter region linked to the luciferase gene. Chinese herbal extracts were used to treat the cells at 24 h after transfection, followed by measurement of their luciferase activity. The screening results were verified by Western blotting to measure HER2 and ERα protein expression. Results. At concentrations that induced little cytotoxicity, thirteen single herbal extracts and five compound recipes were found to increase either ERBB2 or ESR1 luciferase activity. By Western blotting, Si-Wu-Tang, Kuan-Shin-Yin, and Suan-Tsao-Ren-Tang were found to increase either HER2 or ERα protein expression. In addition, Ligusticum chuanxiong was shown to have a great effect on ERBB2 gene expression and synergistically with estrogen to stimulate MCF-7 cell growth. Conclusion. Our results provide important information that should affect clinical treatment strategies among breast cancer patients who are receiving hormonal or targeted therapies.

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Danshen mediates through estrogen receptors to activate Akt and inhibit apoptosis effect of Leu27IGF-II-induced IGF-II receptor signaling activation in cardiomyoblasts

Cited by 24 publications

References 48 publications

Anti-apoptotic effect of San Huang Shel Shin Tang cyclodextrin complex (SHSSTc) on CCl₄-induced hepatotoxicity in rats

Anti-apoptotic effect of San Huang Shel Shin Tang cyclodextrin complex (SHSSTc) on CCl₄-induced hepatotoxicity in rats

Overexpression of the Insulin-Like Growth Factor II Receptor Increases β-Amyloid Production and Affects Cell Viability

Screening to Identify Commonly Used Chinese Herbs That Affect ERBB2 and ESR1 Gene Expression Using the Human Breast Cancer MCF‐7 Cell Line

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Danshen mediates through estrogen receptors to activate Akt and inhibit apoptosis effect of Leu27IGF-II-induced IGF-II receptor signaling activation in cardiomyoblasts

Cited by 24 publications

References 48 publications

Anti-apoptotic effect of San Huang Shel Shin Tang cyclodextrin complex (SHSSTc) on CCl4-induced hepatotoxicity in rats

Anti-apoptotic effect of San Huang Shel Shin Tang cyclodextrin complex (SHSSTc) on CCl4-induced hepatotoxicity in rats

Overexpression of the Insulin-Like Growth Factor II Receptor Increases β-Amyloid Production and Affects Cell Viability

Screening to Identify Commonly Used Chinese Herbs That Affect ERBB2 and ESR1 Gene Expression Using the Human Breast Cancer MCF‐7 Cell Line

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Product

Resources

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Anti-apoptotic effect of San Huang Shel Shin Tang cyclodextrin complex (SHSSTc) on CCl₄-induced hepatotoxicity in rats

Anti-apoptotic effect of San Huang Shel Shin Tang cyclodextrin complex (SHSSTc) on CCl₄-induced hepatotoxicity in rats