Danshensu protects against 6-hydroxydopamine-induced damage of PC12 cells in vitro and dopaminergic neurons in zebrafish

Chong, Cheong-Meng; Zhou, Zhong-Yan; Razmovski-Naumovski, Valentina; Cui, Guozhen; Zhang, Lun-Qing; Sa, Fei; Hoi, Maggie Pui Man; Chan, Kelvin; Lee, Simon Ming‐Yuen

doi:10.1016/j.neulet.2013.02.069

Cited by 65 publications

(37 citation statements)

References 34 publications

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“…Through drug screening in this model, several compounds with neuroprotective effects such as iNOS inhibitors and anticancer agents have been successfully identified [34][35][36][37][38][39].…”

Section: 6 Bhdpc Increased the Expression Of Bcl2 Via Regulation Omentioning

confidence: 99%

Discovery of a novel neuroprotectant, BHDPC, that protects against MPP+/MPTP-induced neuronal death in multiple experimental models

Chong

Zhao

et al. 2015

Free Radical Biology and Medicine

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Section: 6 Bhdpc Increased the Expression Of Bcl2 Via Regulation Omentioning

confidence: 99%

Discovery of a novel neuroprotectant, BHDPC, that protects against MPP+/MPTP-induced neuronal death in multiple experimental models

Chong

Zhao

et al. 2015

Free Radical Biology and Medicine

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“…Following treatment, western blot analysis were performed as described in our previous publication [5]. Photographs of protein bands were taken by a Molecular Imager ChemiDoc XRS (BioRad Hercules, CA).…”

Section: Western Blot Analysismentioning

confidence: 99%

Discovery of novel anti-parkinsonian effect of schisantherin A in in vitro and in vivo

Zhang

Chong

et al. 2015

Neuroscience Letters

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“…The up-regulation of NRF2 alleviates oxidative stress and reduces the risk of chronic diabetic complications [38] . Danshensu pretreatment significantly attenuated 6-hydroxydopamine-induced reactive oxygen species (ROS) production in PC12 cells, which was mediated by activating the nuclear translocation of NRF2 [39] . Salvianolic acid A increased the protein expression of NRF2 to inhibit H 2 O 2 -mediated damage in primary cultured retinal pigment epithelial cells [40] .…”

Section: Discussionmentioning

confidence: 99%

Deciphering the therapeutic mechanisms of Xiao-Ke-An in treatment of type 2 diabetes in mice by a Fangjiomics approach

et al. 2015

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Aim: Xiao-Ke-An (XKA) is a traditional Chinese medicine (TCM) formula for the treatment of type 2 diabetes (T2D), and the effective ingredients and their targets as well as the mechanisms of XKA remain to be elucidated. In this study we investigated the therapeutic mechanisms of XKA in the treatment of T2D in mice using a Fangjiomics approach. Methods: KKAy mice feeding on a high-fat diet were used as models of T2D, and were orally treated with XKA (0.75 or 1.5 g·kg -1 ·d -1 ) for 32 d. Microarray mRNA expression data were obtained from the livers of the mice. Differentially expressed genes (DEGs) were identified by reverse rate analysis and ANOVA analysis. The compounds in XKA were identified by LC-MS analysis or collected from TCM databases. The relationships between the compounds and targets were established by combining the DEGs with information derived from mining literature or herb target databases. Relevant pathways were identified through a Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis using WebGestalt. Results: The compound-target-pathway network based on compounds identified by LC-MS analysis (NCA) included 20 constituent compounds, 46 targets and 36 T2D-related pathways, whereas the compound-target-pathway network based on compounds collected from databases (NCD) consisted of 40 compounds, 68 targets and 21 pathways. In the treatment of T2D, XKA might act mainly by improving carbohydrate and lipid metabolism, as well as ameliorating insulin resistance, inflammation and diabetic vascular complications. Conclusion: The network-based approach reveals complex therapeutic mechanisms of XKA in the treatment of T2D in mice that involve numerous compounds, targets, and signaling pathways.

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Danshensu protects against 6-hydroxydopamine-induced damage of PC12 cells in vitro and dopaminergic neurons in zebrafish

Cited by 65 publications

References 34 publications

Discovery of a novel neuroprotectant, BHDPC, that protects against MPP+/MPTP-induced neuronal death in multiple experimental models

Discovery of a novel neuroprotectant, BHDPC, that protects against MPP+/MPTP-induced neuronal death in multiple experimental models

Discovery of novel anti-parkinsonian effect of schisantherin A in in vitro and in vivo

Deciphering the therapeutic mechanisms of Xiao-Ke-An in treatment of type 2 diabetes in mice by a Fangjiomics approach

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