Abstract:The action of the relaxing agent dantrolene on dipalmitoylphosphatidylcholine (DPPC) model membranes in the presence and absence of the general anesthetic halothane has been investigated by DSC and 31P-NMR. Dantrolene has a weak effect on both the thermodynamic and NMR parameters of the pure model membrane. When halothane is present in the system, the relaxing agent acts to counterbalance the strong anesthetic-induced membrane perturbation. This is reflected in DSC experiments by a change of the enthalpy varia… Show more
“…In the latter cases, the disappearance of the pre-transition peak and the important broadening of the transition peak are characteristic of the incorporation phenomenon which represents a perturbation of the lipidic matrix and loss of cooperativity. 26 The temperatures of the pre-transition and transition and the value of the enthalpy were determined for each sample. The main results are displayed in Table 2.…”
Section: Incorporation Of Derivatives 4 Into Preorganized Molecular S...mentioning
“…In the latter cases, the disappearance of the pre-transition peak and the important broadening of the transition peak are characteristic of the incorporation phenomenon which represents a perturbation of the lipidic matrix and loss of cooperativity. 26 The temperatures of the pre-transition and transition and the value of the enthalpy were determined for each sample. The main results are displayed in Table 2.…”
Section: Incorporation Of Derivatives 4 Into Preorganized Molecular S...mentioning
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