2024
DOI: 10.1080/14740338.2024.2412228
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Dapagliflozin cardiovascular effects on end-stage kidney disease (DARE-ESKD-2) trial: rationale and design

Joaquim Barreto,
Marilia Martins,
Mauro Pascoa
et al.

Abstract: Sodium glucose co-transporter 2 inhibitors (SGLT2i) remarkably reduced the incidence of hospitalization for heart failure and cardiovascular death of conservatively managed chronic kidney disease. We hypothesized that adding SGLT2i to standard treatment would yield cardiovascular bene ts also in endstage kidney disease (ESKD) individuals on dialysis. Methods.The DARE-ESKD-2 Trial (NCT05685394) is an ongoing, single-center, open-label, controlled trial aimed at assessing the cardiovascular effects of dapagli oz… Show more

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