Dapagliflozin Influence on the Clinical Course of Diabetes Mellitus Type 2 and Essential Hypertension in Patients

Virstyuk, N. G.; Ikwuka, Aloysius Obinna

doi:10.1007/978-3-319-70548-4_582

Cited by 8 publications

(5 citation statements)

References 6 publications

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“…Dapagliflozin and Glucagon-like Peptide 1 Receptor Agonists (GLP-1 RAs) e.g. Liraglutide have been found to improve the efficacy of treatment and clinical course of type 2 diabetes mellitus and hypertension in patients with such comorbidities [17,22,26,31,57,58,59]. It has also been documented that coconut water has hepatorenal protective functions in alloxaninduced type 1 diabetes mellitus [13].…”

Section: Discussionmentioning

confidence: 99%

Optimization of Delirium Care in Adult Patients with Cancer: A Comprehensive and Integrative Review of Efficacy and Patient Outcomes

Ojiaku,

Duru,

Ikwuka

et al. 2024

WJCMR

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Delirium is a major complication most commonly observed in patients with advanced cancer. However, despite its prevalence, the early diagnosis, management, and prevention of this condition have not seen significant progress. Aim of this research is to provide insights into the prevalence of delirium, the optimization of interventions for managing delirium symptoms, their effectiveness and the impact of underlying factors on the reversibility of delirium in advanced cancer patients receiving palliative care. The review involved systematic searches of relevant databases including MEDLINE, CINAHL, ProQuest Nursing and Allied Health, and PsychInfo using refined search terms. Eight publications out of 614 studies originally searched were selected and critically reviewed. Their quality was assessed using Joanna Briggs Institute's Critical Appraisal Tool for Case Series. Data abstraction and content analysis were performed to synthesize the findings. Delirium is prevalent among advanced cancer patients in palliative care, with rates ranging from 10.3% to 24.1%. Pharmacotherapy and non-pharmacological interventions showed effectiveness in reducing delirium symptoms. Delirium was found to be reversible through palliative care interventions, antipsychotic medications, and exercise therapy. Effective delirium management is crucial in improving the quality of life of cancer patients. This review emphasizes the importance of subtype-specific treatments, standardized guidelines, and long-term follow-up studies. Implementing evidence-based individualized approaches to delirium management can optimize treatment efficacy and clinical outcomes in patients as well as improve the quality of care. Tailored interventions, standardized protocols, and further research are hereby recommended.

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Section: Discussionmentioning

confidence: 99%

Optimization of Delirium Care in Adult Patients with Cancer: A Comprehensive and Integrative Review of Efficacy and Patient Outcomes

Ojiaku,

Duru,

Ikwuka

et al. 2024

WJCMR

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“…This adipose tissue itself promotes insulin resistance through various inflammatory mechanisms, including increased free fatty acids (FFAs) release and adipokine dysregulation. Lack of physical activity, prior to GDM in those with hypertension or dyslipidemia also increases the risk of developing T2DM [23,31,32,35,39,69].…”

Section: Discussionmentioning

confidence: 99%

Profiling of Clinical Dynamics of Type 2 Diabetes Mellitus in Patients: a Perspective Review

Ikwuka,

Omoju,

Mahanera

2023

World Journal of Current Med and Pharm Research

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Type 2 diabetes mellitus (T2DM), also known as Non-Insulin Dependent Diabetes Mellitus (NIDDM) is one of the common metabolic disorders in the world. T2DM accounts for around 90% of all cases of diabetes mellitus, afflicting millions worldwide. It is a significant global health burden with a steadily increasing prevalence. In T2DM, the response to insulin is diminished, and this is defined as insulin resistance. Risk factors for T2DM are diverse. Some are modifiable, and others are not. Modifiable risk factors include overweight/obesity, lack of exercise or physical inactivity, poor nutrition, etc. Non-modifiable risk factors include age, ethnicity/race, family history, history of gestational diabetes mellitus, etc. The starting points and mainstays of treatment for T2DM are diet and lifestyle modifications such as increased physical activity and stoppage of smoking. In addition to the diet and lifestyle modifications, drugs are also used in the management of T2DM. This study aimed to profile the clinical dynamics of type 2 diabetes mellitus in patients. Current literatures from different databases including MEDLINE, PubMed, EMBASE, CINAHL, Google Scholar, etc. on the topic were searched online and reviewed.

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“…Features of kidney damage in other pathological conditions such as metabolic syndrome diseases e.g. essential hypertensive disease and type 2 diabetes mellitus have been extensively studied [10,11,13,19,24,27,43]. Nevertheless, sodium-glucose linked transporter-2 (SGLT-2) inhibitors and glucagon-like peptide-1 receptor agonists (GLP-1 RAs) have been found effective in treating patients with such co-morbid pathologies [12,16,17,21,25,48,49,50].…”

Section: Introductionmentioning

confidence: 99%

“…essential hypertensive disease and type 2 diabetes mellitus have been extensively studied [10,11,13,19,24,27,43]. Nevertheless, sodium-glucose linked transporter-2 (SGLT-2) inhibitors and glucagon-like peptide-1 receptor agonists (GLP-1 RAs) have been found effective in treating patients with such co-morbid pathologies [12,16,17,21,25,48,49,50]. Many ecological factors (both abiotic and biotic) go a long way to influence the density, distribution and abundance of intermediate host freshwater snails [31,34].…”

Section: Introductionmentioning

confidence: 99%

Parasitic and Ecological Factors Associated with Transmission of Urogenital Schistosomiasis in Owena Reservoir Area, Ondo State, Nigeria

Peletu,

Ofoezie,

Ikwuka

2023

World Journal of Current Med and Pharm Research

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Human urogenital schistosomiasis caused by infection of the trematode worm Schistosoma hematobium is a major source of morbidity and mortality in Ondo State especially in Owena Reservoir Area, Ondo East Local Government Area, Ondo State, Nigeria. The aim of this study was to investigate: (i) the seasonal and spatial distribution, infection and cercariae shedding patterns of identified local Schistosoma intermediate snail host(s); (ii) to determine the influence of ecological factors on the identified intermediate snail species in the transmission of urogenital schistosomiasis along the Owena Reservoir and river courses. All the snails collected were placed in pre-labeled plastic containers and were transported to a Malacology Laboratory at Ile-Ife, Osun State, Nigeria. The snails were identified to species level, counted and recorded as number of snails, per site, per date. The snails were identified using standard identification keys. Examination of snails for Schistosoma infection was carried out by crushing method. Cercariae were identified to genus level. However, only snails shedding Schistosoma cercariae were recorded as infected. Each of the eight sites was sampled once monthly for twenty-four months. Eight stations (sites) of diverse ecological characteristics were selected along the Owena Reservoir and monitored for snails species’ diversity, distribution and infection patterns, physicochemical properties of H2O, macrophyte types and coverage in relation to the transmission of urogenital schistosomiasis. Seven snail species representing two sub-classes, three families and five genera were identified in Owena Reservoir Area. Bulinus globosus and Bulinus truncatus were the only established Schistosoma intermediate snail hosts in site 4 (KAJ 1) located in Kajola community. Out of the eight sites studied, site 4 in Kajola community had the highest infection rate while Embankment/Dam (site 8) had the least. Site 4 in Kajola community is therefore the major transmission site. All the snail species correlated positively with alkalinity conduction, negatively with air temperature. Bulinus globosus correlated significantly positive with Ludwiga erecta, Ludwiga decurrens, Commelina africana, and Berberis calamus (p<0.05) but correlated significantly negative with Panicum maximus and Ervatomia hirta (p>0.05). Bulinus truncatus correlated significantly positive with Aspillia africana, Ludwiga decurrens, Emilia occinina, and Crosus sativue (p<0.05) but correlated significantly negative with Ludwiga erecta, Panicum maximus, and Commelina africana (p>0.05). This study recommends environmental management and manipulation using water level regulations to render water contact sites environmentally unfriendly for both snail growth and human recreational activities during the period of high risk transmission since chemical control (the use of molluscicide) poses a risk to health, not only to the snail intermediate hosts but also to the inhabitants of the communities who commonly depend on reservoirs, streams, rivers, dams for their domestic water supply.

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Dapagliflozin Influence on the Clinical Course of Diabetes Mellitus Type 2 and Essential Hypertension in Patients

Cited by 8 publications

References 6 publications

Optimization of Delirium Care in Adult Patients with Cancer: A Comprehensive and Integrative Review of Efficacy and Patient Outcomes

Optimization of Delirium Care in Adult Patients with Cancer: A Comprehensive and Integrative Review of Efficacy and Patient Outcomes

Profiling of Clinical Dynamics of Type 2 Diabetes Mellitus in Patients: a Perspective Review

Parasitic and Ecological Factors Associated with Transmission of Urogenital Schistosomiasis in Owena Reservoir Area, Ondo State, Nigeria

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