2020
DOI: 10.1007/s00204-020-02951-8
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Dapagliflozin suppresses ER stress and protects doxorubicin-induced cardiotoxicity in breast cancer patients

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Cited by 53 publications
(38 citation statements)
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“…The present study showed that WG reversed the opening of mPTP and reduced the release of apoptotic factors cytochrome c into the cytoplasm, so as to prevent apoptosis. DOX can directly activate cardiomyocyte apoptosis by reducing Bcl-2/Bax ratio ( 49 ). Previous studies have noted that the high expression of Bcl-2 can enhance the resistance of cells to most DNA damage factors and inhibit the apoptosis of target cells caused by most chemotherapeutic drugs and that the Bax gene, which inhibits Bcl-2, is the main apoptosis gene in human body ( 50 , 51 ).…”
Section: Discussionmentioning
confidence: 99%
“…The present study showed that WG reversed the opening of mPTP and reduced the release of apoptotic factors cytochrome c into the cytoplasm, so as to prevent apoptosis. DOX can directly activate cardiomyocyte apoptosis by reducing Bcl-2/Bax ratio ( 49 ). Previous studies have noted that the high expression of Bcl-2 can enhance the resistance of cells to most DNA damage factors and inhibit the apoptosis of target cells caused by most chemotherapeutic drugs and that the Bax gene, which inhibits Bcl-2, is the main apoptosis gene in human body ( 50 , 51 ).…”
Section: Discussionmentioning
confidence: 99%
“…Indeed, Dapa has decreased the cardiac expression of cleaved caspase-3 and protected against doxorubicin-induced cardio-toxicity in breast cancer patients [ 34 ]. In pre-ischemia, Dapa conferred the maximum level of cardio-protection through decreasing cardiac apoptosis and caspase-3 expression [ 35 ], as well as attenuated experimental inflammatory bowel disease in rats and dampened colonic apoptosis by lowering the caspase-3 activity and cleaved caspase-3 expression [ 36 ].…”
Section: Discussionmentioning
confidence: 99%
“…It has been reported that dapagliflozin protects against doxorubicin-induced cardiotoxicity in patients with breast cancer and diabetes. Moreover, dapagliflozin inhibits doxorubicin-induced myocardial fibrosis and greatly improves cardiac function by inhibiting the apoptosis of cardiomyocytes and the generation of ROS ( 122 ). Therefore, topoisomerase inhibitors and dapagliflozin can protect the heart from the toxicity of chemotherapy drugs by inhibiting myocardial remodeling.…”
Section: Prevention Strategiesmentioning
confidence: 99%