Daphnia magna model in the toxicity assessment of pharmaceuticals: A review

Tkaczyk, Angelika; Bownik, Adam; Dudka, Jarosław; Kowal, Krzysztof; Ślaska, Brygida

doi:10.1016/j.scitotenv.2020.143038

Cited by 184 publications

(87 citation statements)

References 75 publications

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“…Thus, the similarities between the genes and phenotypes of this model and those of humans make it a good model organism for disease and toxicity studies [ 132 , 133 ]. Another famous model is Daphnia magna , which is one of the oldest model organisms used in biological research [ 134 ]. The toxicity of this model can be evaluated based on various types of behavioral and physiological responses [ 135 , 136 ].…”

Section: Exposure On Emerging Environmental Pollutantmentioning

confidence: 99%

Metabolomic Studies for the Evaluation of Toxicity Induced by Environmental Toxicants on Model Organisms

Kim

Kang

2021

Metabolites

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Environmental pollution causes significant toxicity to ecosystems. Thus, acquiring a deeper understanding of the concentration of environmental pollutants in ecosystems and, clarifying their potential toxicities is of great significance. Environmental metabolomics is a powerful technique in investigating the effects of pollutants on living organisms in the environment. In this review, we cover the different aspects of the environmental metabolomics approach, which allows the acquisition of reliable data. A step-by-step procedure from sample preparation to data interpretation is also discussed. Additionally, other factors, including model organisms and various types of emerging environmental toxicants are discussed. Moreover, we cover the considerations for successful environmental metabolomics as well as the identification of toxic effects based on data interpretation in combination with phenotype assays. Finally, the effects induced by various types of environmental toxicants in model organisms based on the application of environmental metabolomics are also discussed.

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Section: Exposure On Emerging Environmental Pollutantmentioning

confidence: 99%

Metabolomic Studies for the Evaluation of Toxicity Induced by Environmental Toxicants on Model Organisms

Kim

Kang

2021

Metabolites

View full text Add to dashboard Cite

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“…Additionally, its transparency allows the observation of optical parameters efficiently via noninvasive methods [ 27 ]. Given these advantages, acute and reproductive toxicity tests for the use of D. magna as an environmental testing organism are well-established by the Organisation for Economic Co-operation and Development (OECD) and International Organization for Standardization (ISO) [ 28 ]. Furthermore, behavioral and physiological changes in D. magna have been reported with respect to the toxicity of various substances under sublethal concentrations [ 29 , 30 , 31 , 32 ].…”

Section: Introductionmentioning

confidence: 99%

Physiological and Behavioral Effects of SiO2 Nanoparticle Ingestion on Daphnia magna

et al. 2021

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The increasingly widespread use of engineered nanoparticles in medical, industrial, and food applications has raised concerns regarding their potential toxicity to humans and the environment. Silicon dioxide nanoparticles (SiO2 NPs), which have relatively low direct toxicity, have been increasingly applied in both consumer products and biomedical applications, leading to significantly higher exposure for humans and the environment. We carried out a toxicity assessment of SiO2 NPs using the common water flea D. magna by focusing on physiological and behavioral indicators such as heart rate, swimming performance, and growth. Exposure to SiO2 NPs did not produce acute or chronic toxicity at limited concentrations (<100 μg/mL), but did have statistically significant negative effects on heart rate, swimming distance, and body size. The use of fluorescein isothiocyanate in a silica matrix allowed the tracing and visualization of clear SiO2 NP accumulation in D. magna, which was confirmed by ICP-MS. Although exposure to SiO2 NPs seemed to affect cardiac and swimming performance, such end-point experiments may be insufficient to fully understand the toxicity of these nanoparticles. However, the physiological and behavioral changes shown here suggest potential adverse effects on the aquatic environment by substances previously considered nontoxic.

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“…Because of the characteristics of easy cultivation, short life cycle and high sensitivity to pollutants, D. magna is a good model organism for the aquatic environment pollution evaluation (Chai et al, 2021;Tkaczyk et al, 2021). D. magna have been used to assess the acute toxic effects of MTP or CTP (Yang et al, 2017), but studies about the damage of CTP and MTP on daphnia's behavior were limited.…”

Section: Introductionmentioning

confidence: 99%

Combined Toxicity and Toxicity Persistence of Antidepressants Citalopram and Mirtazapine to Zooplankton Daphnia Magna

Ma¹,

Li²,

Wei³

et al. 2021

Preprint

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Citalopram (CTP) and mirtazapine (MTP) are two typical psychoactive drugs used for the treatment of depression. As emerging pollutants, CTP and MTP are of widely concern because they are active substances for organisms. However, the studies about the toxicity potential of CTP/MTP pollution to aquatic organisms were limited. In the present study, the effects of CTP and MTP on the feeding behavior, heartbeat, nutritional enzymes and related gene expressions of Daphnia magna were investigated under single and mixed environmental stress. Meanwhile, the recovery of exposed D. magna was studied to analyze the toxic persistence of those pollutants. After 24 h of exposure, the ingestion rate decreased significantly under 1.45 mg/L of CTP. In the mixed treatment groups, no significant synergistic effect of CTM and MTP on daphnia’ feeding inhibition was found. After 24 h of recovery, the feeding behavior of D. magna was stimulated by compensatory stimulation. At exposure period, the heartbeat rate of exposed D. magna increased significantly, and was recovered during the recovery period. The activity of α-amylase (AMS) and trypsin, and their relative gene expression were significantly changed in most of the exposed daphnia, both in the exposure period and recovery period. But there were different responses between gene transcription with enzyme activity. In general, psychoactive drugs have an obvious toxic threat to aquatic organisms, and after acute exposure, the physiological function of D. magna could be recovered to a certain extent. The results were helpful to evaluate the ecological risk of psychotropic drugs in aquatic environments.

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Daphnia magna model in the toxicity assessment of pharmaceuticals: A review

Cited by 184 publications

References 75 publications

Metabolomic Studies for the Evaluation of Toxicity Induced by Environmental Toxicants on Model Organisms

Metabolomic Studies for the Evaluation of Toxicity Induced by Environmental Toxicants on Model Organisms

Physiological and Behavioral Effects of SiO2 Nanoparticle Ingestion on Daphnia magna

Combined Toxicity and Toxicity Persistence of Antidepressants Citalopram and Mirtazapine to Zooplankton Daphnia Magna

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