Dapson in Heterocyclic Chemistry, Part V: Synthesis, Molecular Docking and Anticancer Activity of Some Novel Sulfonylbiscompounds Carrying Biologically Active Dihydropyridine, Dihydroisoquinoline, 1,3-Dithiolan, 1,3-Dithian, Acrylamide, Pyrazole, Pyrazolopyrimidine and Benzochromenemoieties

Synthesis, Crystal Structure and Anti-Breast Cancer Activity of Some Enaminone Derivatives

“…During the last decade we have been involved in a program aimed at exploring the potentials of enaminone as a building block for heteroaromatics 27 and we have successfully synthesized and reported the corresponding quinoline derivatives [13][14][15][16][17][18] utilizing enaminones as starting materials. Based on the above information and as a continuation of previous work on anticancer agents [28][29][30][31][32][33] , we report here the synthesis, spectral characterization and X-ray crystal structures of the three enaminone derivatives of expected anticancer activity. and used without further purification.…”

Crystal structure of (Z)-4-(4-oxopent-2-en-2-ylamino)benzenesulfonamide, C11H14N2O3S

“…Combination of a 4-(4-oxopent-2-en-2-ylamino) sca old with the biologically active sulfonamide moiety has received great attention as PI3 K inhibitor, which is an important enzyme controlling signal transduction [4,[6][7][8]. Recently, diaryl sulfone derivatives, that were synthesized from dapson have shown good cytotoxic activity on breast cancer cell line (MCF-7) [9]. As a continuation of our work to design and synthesize novel anticancer agents [6][7][8][9][10][11][12], we have designed and synthesized the title compound.…”

“…Recently, diaryl sulfone derivatives, that were synthesized from dapson have shown good cytotoxic activity on breast cancer cell line (MCF-7) [9]. As a continuation of our work to design and synthesize novel anticancer agents [6][7][8][9][10][11][12], we have designed and synthesized the title compound. The aim of this work was to design and synthesize of (Z)-4-(4-oxopent-2-en-2-ylamino)benzenesulfonamide having a biologically active sulfonamide moiety.…”

Crystal structure of 2-((2-chloropyridin-3-ylamino)methylene)malononitrile, C9H5ClN4

“…These ndings led us to continue our work on the synthesis of biologically active compounds [7][8][9][10]. The aim of this work was to, synthesize the corresponding compound having a biologically active methylenemalononitrile moiety.…”