Dapsone‐induced drug reaction with eosinophilia and systemic symptoms associated with HLA‐B*13:01

Cai, Fenfen; Lucas, Michaela; Yun, James

doi:10.1111/imj.13730

Cited by 10 publications

(6 citation statements)

References 5 publications

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“…In nonleprosy patients, the HLA-B*13:01 allele was severely associated with dapsone-induced DRESS [ 74 ]. This allele is mostly absent in Europeans and Africans, but it has an allele frequency of 1–12% in Indians, 2– 4% in Southeast Asians, 1.5% in Japanese, and a markedly high prevalence of up to 28% in Australian Aborigines, Taiwanese, and Papuans [ 75 ].…”

Section: Discussionmentioning

confidence: 99%

Antibacterial antibiotic-induced drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome: a literature review

Sharifzadeh

Mohammadpour

Tavanaee

et al. 2020

Eur J Clin Pharmacol

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Background Drug reaction with eosinophilia and systemic symptoms syndrome (DRESS) is a delayed infrequent potentially lifethreatening idiosyncratic drug reaction. Aromatic anticonvulsants and allopurinol are the most frequent causative agents. However, various reports of antibiotic-induced DRESS are available. In this review, we try to summarize reports of antibacterial antibiotic-induced DRESS focusing on characteristics of DRESS induced by each antibiotic group. Methods The data were collected by searching PubMed/MEDLINE and ScienceDirect. The keywords used as search terms were "DRESS syndrome," "drug-induced hypersensitivity syndrome (DIHS)," "antibiotics," "antimicrobial," and names of various antimicrobial groups. Finally, 254 relevant cases with a definite or probable diagnosis of DRESS based on RegiSCAR criteria were found until 30 May 2020 and reviewed. Results and conclusion Totally, 254 cases of antibacterial antibiotic-induced DRESS are reported. Most of them are related to antituberculosis drugs, vancomycin, and sulfonamides, respectively. Rash and fever were most frequent clinical findings. Eosinophilia and liver injury were the most reported hematologic and visceral organ involvement, respectively. Most of the patients are managed with systemic corticosteroids. The death occurred in 16 patients which most of them experienced liver or lung involvement. The reactivation of various viruses especially HHV-6 is reported in 33 cases. The mean latency period was 29 days. It is necessary to perform thorough epidemiological, genetic, and immunological studies, also systematic case review and causality assessment, as well as well-designed clinical trials for better management of antibiotic-induced DRESS.

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Section: Discussionmentioning

confidence: 99%

Antibacterial antibiotic-induced drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome: a literature review

Sharifzadeh

Mohammadpour

Tavanaee

et al. 2020

Eur J Clin Pharmacol

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“…111 In patients with dapsone-induced DRESS, associations with HLA-B*1301 have been found, indicating the importance of genetic screening before dapsone therapy for patient safety. [112][113][114] The HLA-B*58:01 allele has been associated with allopurinolinduced DRESS and SJS/TEN, 115,116 and its predictive value is being evaluated in different populations. 111,117 CONTROVERSIAL AREAS There is general consensus about the need for better in vitro tests for diagnostic evaluation of DHRs.…”

Section: Hla Markersmentioning

confidence: 99%

Controversies in drug allergy: In vitro testing

Mayorga

Ebo

Lang

et al. 2019

Journal of Allergy and Clinical Immunology

107

106

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Despite their low frequency, drug hypersensitivity reactions (DHRs) can be serious and result in lifelong sequelae. The diagnosis is critical to avert future reactions and should identify the culprit drug or drugs and safe alternatives. However, making the diagnosis can be complex and challenging. Reliable in vitro tests can offer the potential to improve a diagnosis of DHR and influence medical decision making. Importantly, in vitro testing is frequently not performed as a test in isolation but rather as a component of a diagnostic algorithm along with additional tests. There are several in vitro approaches for the different endotypes of DHRs. However, only few are available for routine diagnosis, and many are restricted to research laboratories. In vitro tests exhibit varying sensitivity and specificity depending on the drug involved and the clinical phenotype. In vitro tests can complement skin tests, especially in patients with negative or equivocal skin test responses inconsistent with the clinical presentation and in severe reactions in which drug provocation tests are contraindicated. The main unmet need for many in vitro tests for the diagnosis of DHRs is validation in larger studies with standardized controls that could harmonize diagnostic management between the United States, European Union, and other regions of the world.

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“…Two copies of HLA-B*13 : 01 makes individuals 101-times more susceptible to the syndrome. The results have been independently validated in various Asian populations including Thais[ 15 ], Koreans[ 16 ], Indians[ 17 ] and Taiwanese[ 18 ]. Screening for this allele in new leprosy patients before the initiation of MDT has proven beneficial to reduce incidence rate of DHS in China to zero[ 19 ].…”

Section: Introductionmentioning

confidence: 99%

Validation study of HLA-B*13:01 as a biomarker of dapsone hypersensitivity syndrome in leprosy patients in Indonesia

Krismawati¹,

Irwanto

Pongtiku

et al. 2020

PLoS Negl Trop Dis

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Leprosy is a stigmatizing, chronic infection which degenerates the nervous system and often leads to incapacitation. Multi-drug therapy which consists of dapsone, rifampicin and clofazimine has been effective to combat this disease. In Indonesia, especially in Papua Island, leprosy is still a problem. Furthermore, there had been higher reports of Dapsone Hypersensitivity Syndrome (DHS) which also challenges leprosy elimination in certain aspects. Globally, DHS has a prevalence rate of 1.4% and a fatality rate up to 13%. The aim of this study is to validate HLA-B*13 : 01 , a previously discovered biomarker for DHS in the Chinese population, as a biomarker for DHS in the Papua population.This is a case-control study of 34 leprosy patients who presented themselves with DHS (case subjects) and 52 leprosy patients without DHS (control subjects). Patients were recruited from 2 provinces: Papua and West Papua. DNA was extracted from 3 ml blood specimens. HLA-B alleles were typed using the gold-standard sequence based typing method. Results were then analysed using logistic regression and risk assessment was carried out. The results of HLA-typing showed that HLA-B*13 : 01 was the most significant allele associated with DHS, with odds ratio = 233.64 and P-value = 7.11×10 −9 , confirming the strong association of HLA-B*13 : 01 to DHS in the Papua population. The sensitivity of this biomarker is 91.2% and specificity is 96.2%, with an area under the curve of 0.95. HLA-B*13 : 01 is validated as a biomarker for DHS in leprosy patients in Papua, Indonesia, and can potentially be a good predictor of DHS to help prevent this condition in the future.

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Dapsone‐induced drug reaction with eosinophilia and systemic symptoms associated with HLA‐B*13:01

Cited by 10 publications

References 5 publications

Antibacterial antibiotic-induced drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome: a literature review

Antibacterial antibiotic-induced drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome: a literature review

Controversies in drug allergy: In vitro testing

Validation study of HLA-B*13:01 as a biomarker of dapsone hypersensitivity syndrome in leprosy patients in Indonesia

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