Dapsone-responsive inflammatory dermatitis with features of subcorneal pustular dermatosis and bullous pemphigoid

Ghatnekar, Shilpa; Rutherford, Audrey; Vandergriff, Travis; Yancey, Kim B.

doi:10.1016/j.jdcr.2022.01.026

Cited by 2 publications

(1 citation statement)

References 10 publications

(13 reference statements)

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“…Without treatment periods of exacerbation repeat for several years, while the duration of remissions varies from several days to several weeks. The drugs of choice are sulfones (predominantly dapsone) [10], in the treatment of which most often a complete remission is achieved. Acitretinmaybeasecond-line drug.…”

Section: Introductionmentioning

confidence: 99%

Subcorneal pustular dermatosis (Sneddon-Wilkinson disease): a case report

Potekaev¹,

Morozova²,

Bobko³

et al. 2023

Ann Dermatol Res

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This article contains modern data on the etiology, clinical presentation and treatment as well as the differential diagnosis of a rare dermatosis, Sneddon-Wilkinson disease. Clinical observation of subcorneal pustular dermatosis in a 68-year-old woman is reported. Histopathological examination played a key role in making the correct diagnosis. Treatment consisted of a physiotherapeutic approach (311 nm UVB phototherapy) in combination with systemic glucocorticosteroids (dexamethasone). This therapeutic approach (instead of dapsone therapy) can be used due to its relatively good safety profile.

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Section: Introductionmentioning

confidence: 99%

Subcorneal pustular dermatosis (Sneddon-Wilkinson disease): a case report

Potekaev¹,

Morozova²,

Bobko³

et al. 2023

Ann Dermatol Res

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Repurposing Historic Drugs for Neutrophil-Mediated Inflammation in Skin Disorders

Franceschin,

Guidotti,

Mazzetto

et al. 2024

Biomolecules

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Neutrophil-mediated inflammation is a key feature of immune-mediated chronic skin disorders, but the mechanistic understanding of neutrophil involvement in these conditions remains incomplete. Dapsone, colchicine, and tetracyclines are established drugs within the dermatologist’s therapeutic armamentarium that are credited with potent anti-neutrophilic effects. Anti-neutrophilic drugs have established themselves as versatile agents in the treatment of a wide range of dermatological conditions. Some of these agents are approved for the management of specific dermatologic conditions, but most of their current uses are off-label and only supported by isolated reports or case series. Their anti-inflammatory and immunomodulatory properties make them particularly valuable in managing auto-immune bullous diseases, neutrophilic dermatoses, eosinophilic dermatoses, interface dermatitis, and granulomatous diseases that are the focus of this review. By inhibiting inflammatory pathways, reducing cytokine production, and modulating immune responses, they contribute significantly to the treatment and management of these complex skin conditions. Their use continues to evolve as our understanding of these diseases deepens, and they remain a cornerstone of dermatological therapy.

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Dapsone-responsive inflammatory dermatitis with features of subcorneal pustular dermatosis and bullous pemphigoid

Cited by 2 publications

References 10 publications

Subcorneal pustular dermatosis (Sneddon-Wilkinson disease): a case report

Subcorneal pustular dermatosis (Sneddon-Wilkinson disease): a case report

Repurposing Historic Drugs for Neutrophil-Mediated Inflammation in Skin Disorders

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