Daratumumab-Induced Interference in Flow-Cytometry Crossmatch and Resolving It by DTT Treatment
Jong Kwon Lee,
In Hwa Jeong,
Noorie Kang
et al.
Abstract:Background: Daratumumab is a human monoclonal antibody targeting CD38 used widely in various related conditions. Caution is advised when interpreting the pretransfusion tests in daratumumab-treated patients because they may show nonspecific reactions with red blood cells. This paper provides experimental evidence for the false-positive interference phenomena induced by daratumumab in in-vitro and ex-vivo experiments and experimental support for resolving it using dithiothreitol (DTT). Methods: Fifteen crossmat… Show more
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