The present study investigates the entropy generation of chemically reactive micropolar hybrid nanoparticle motion with mass transfer. Magnetic oxide (Fe3O4) and copper oxide (CuO) nanoparticles were mixed in water to form a hybrid nanofluid. The governing equations for velocity, concentration, and temperature are transformed into ordinary differential equations along with the boundary conditions. In the fluid region, the heat balance is kept conservative with a source/sink that relies on the temperature. In the case of radiation, there is a differential equation along with several characteristic coefficients that transform hypergeometric and Kummer’s differential equations by a new variable. Furthermore, the results of the current problem can be discussed by implementing a graphical representation with different factors, namely the Brinkman number, porosity parameter, magnetic field, micropolar parameter, thermal radiation, Schmidt number, heat source/sink parameter, and mass transpiration. The results of this study are presented through graphical representations that depict various factors influencing the flow profiles and physical characteristics. The results reveal that an increase in the magnetic field leads to a reduction in velocity and entropy production. Furthermore, temperature and entropy generation rise with a stronger radiation parameter, whereas the Nusselt number experiences a decline. This study has several industrial applications in technology and manufacturing processes, including paper production, polymer extrusion, and the development of specialized materials.