Darier-White disease in siblings responding to isotretinoin

Bhat, Ramesh M; Ullal, K R; Pinto, Anita C; Sukumar, D

doi:10.4103/2229-5178.73252

Cited by 7 publications

(3 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…As a chronic disease, there is a need for continuous use with surveillance of hepatotoxicity, hypertriglyceridemia, and teratogenicity. 222 , 223 , 224 …”

Section: Results Of Studies Justifying Recommendationmentioning

confidence: 99%

Consensus on the use of oral isotretinoin in dermatology - Brazilian Society of Dermatology

Bagatin

Costa

Rocha

et al. 2020

Anais Brasileiros de Dermatologia

View full text Add to dashboard Cite

Background Isotretinoin is a synthetic retinoid, derived from vitamin A, with multiple mechanisms of action and highly effective in the treatment of acne, despite common adverse events, manageable and dose-dependent. Dose-independent teratogenicity is the most serious. Therefore, off-label prescriptions require strict criteria. Objective To communicate the experience and recommendation of Brazilian dermatologists on oral use of the drug in dermatology. Methods Eight experts from five universities were appointed by the Brazilian Society of Dermatology to develop a consensus on indications for this drug. Through the adapted DELPHI methodology, relevant elements were listed and an extensive analysis of the literature was carried out. The consensus was defined with the approval of at least 70% of the experts. Results With 100% approval from the authors, there was no doubt about the efficacy of oral isotretinoin in the treatment of acne, including as an adjunct in the correction of scars. Common and manageable common adverse events are mucocutaneous in nature. Others, such as growth retardation, abnormal healing, depression, and inflammatory bowel disease have been thoroughly investigated, and there is no evidence of a causal association; they are rare, individual, and should not contraindicate the use of the drug. Regarding unapproved indications, it may represent an option in cases of refractory rosacea, severe seborrheic dermatitis, stabilization of field cancerization with advanced photoaging and, although incipient, frontal fibrosing alopecia. For keratinization disorders, acitretin performs better. In the opinion of the authors, indications for purely esthetic purposes or oil control are not recommended, particularly for women of childbearing age. Conclusions Approved and non-approved indications, efficacy and adverse effects of oral isotretinoin in dermatology were presented and critically evaluated.

show abstract

“…As a chronic disease, there is a need for continuous use with surveillance of hepatotoxicity, hypertriglyceridemia, and teratogenicity. 222 , 223 , 224 …”

Section: Results Of Studies Justifying Recommendationmentioning

confidence: 99%

Consensus on the use of oral isotretinoin in dermatology - Brazilian Society of Dermatology

Bagatin

Costa

Rocha

et al. 2020

Anais Brasileiros de Dermatologia

View full text Add to dashboard Cite

show abstract

“…12,18 Isotretinoin. There was also Grade B evidence for the use of the oral retinoid, isotretinoin in treating DD [24][25][26][27][28][29][30][31][32][33] . In trial by Dicken et al, 98 of 104 patients with DD who used isotretinoin experienced improvement of their symptoms after 16 weeks of treatment.…”

Section: Systemic Therapiesmentioning

confidence: 99%

Therapeutic Options for the Treatment of Darier’s Disease: A Comprehensive Review of the Literature

et al. 2021

View full text Add to dashboard Cite

Darier’s disease (also known as keratosis follicularis or dyskeratosis follicularis) is an autosomal dominant inherited disorder which manifests as hyperkeratotic greasy papules in the first or second decade of life. Aside from symptom management and behavioral modifications to avoid triggers, there are currently no validated treatments for Darier’s disease (DD). However, a variety of treatments have been proposed in the literature including retinoids, steroids, vitamin D analogs, photodynamic therapy, and surgical excision. The purpose of this review article is to identify therapeutic options for treating DD and to outline the evidence underlying these interventions. A search was conducted in Medline for English language articles from inception to July 4, 2020. Our search identified a total of 474 nonduplicate studies, which were screened by title and abstract. Of these, 155 full text articles were screened against inclusion/exclusion criteria, and 113 studies were included in our review. We identified Grade B evidence for the following treatments of DD: oral acitretin, oral isotretinoin, systemic Vitamin A, topical tretinoin, topical isotretinoin, topical adapalene gel, topical 5-flououracil, topical calciptriol and tacalcitol (with sunscreen), grenz ray radiation, and x-ray radiation. All other evidence for treatments of DD consisted of case reports or case series, which is considered grade C evidence. Considering the quality and quantity of evidence, clinicians may consider initiating a trial of select topical or oral retinoids first in patients with localized or generalized DD, respectively.

show abstract

“…Bhat et al used oral isotretinoin at a dose of 20 and 40 mg/day along with a steroid taper for 2 patients with diffuse Darier disease with nail involvement with marked improvement. 37 Alitretinoin (9-cis retinoic acid) was used for a total of 7 patients with rather generalized Darier disease, all of which showed marked improvement of symptoms at a dose of 30 mg/day over a period of at least 1 month; 6 of them, however, relapsed. [38][39][40][41][42] Alitretinoin at 30 mg/day was also used in association with 5-FU on a daily basis in a 43-year-old male who achieved complete remission after 4 months.…”

Section: Oral Treatmentsmentioning

confidence: 99%

Management of Darier disease: A review of the literature and update

Haber¹,

Dib²

2021

IJDVL

View full text Add to dashboard Cite

Darier disease (DD) is a rare type of inherited keratinizing disorder with no definitive therapeutic approach. The objective of this study is to provide a detailed literature review of all the available treatment modalities of Darier disease, including those that are both surgical and non surgical, to compare their efficacies and to propose a novel therapeutic approach. A complete search of the literature for all articles describing the different treatments of Darier disease, with no restrictions on patients’ ages, gender or nationalities, was performed with the use of PubMed. A total of 68 articles were included in the study: 3 prospective studies, 44 case reports/case series and 21 letters/correspondences/clinical images. The treatments described were topical, oral or physical. Retinoids (isotretinoin, tazarotene and adapalene) and fluorouracil were the two most effective topical treatments. Oral retinoids were the most effective oral therapy and were prescribed in the cases of generalized Darier disease. For localized and resistant skin lesions, physical therapies including surgical excision, dermabrasion and CO2 laser ablation were the first line choices. Limitations of this article include the inability to verify the accuracy of the published data, the relatively small sample size, the absence of randomized controlled clinical trials and possible unidentified confounding factors in various studies. In every therapeutic approach to Darier disease, consideration of patient comorbidities, disease distribution, severity and treatment accessibility is essential. Large and randomized clinical trials are necessary for the comparison of the efficacy and the safety of all the treatments of Darier disease and settling a consensus for management.

show abstract

Darier-White disease in siblings responding to isotretinoin

Cited by 7 publications

References 5 publications

Consensus on the use of oral isotretinoin in dermatology - Brazilian Society of Dermatology

Consensus on the use of oral isotretinoin in dermatology - Brazilian Society of Dermatology

Therapeutic Options for the Treatment of Darier’s Disease: A Comprehensive Review of the Literature

Management of Darier disease: A review of the literature and update

Contact Info

Product

Resources

About