Dark Without Pressure in a Case of Choroidal Osteoma

Sherman, Tatyana; Palileo, Bea M; Adam, Christopher; Abrams, Gary W.

doi:10.1097/icb.0000000000001026

Cited by 5 publications

(4 citation statements)

References 9 publications

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“…The existence of DWOP lesions has been reported in several diseases, but the incidence rate of DWOP lesions has rarely been reported [ 22 , 23 , 24 ]. In the case series reported by Fawzi A et al [ 7 ] DWOP was found in a 25-year-old girl with myopia and showed no significant progress at the 1-year follow-up.…”

Section: Discussionmentioning

confidence: 99%

“…In the study conducted by Amani A. Fawzi [ 7 ], WWOP was shown to have no relation to vitreal-retinal traction, but was related to the reflectivity changes in the photoreceptor layer, which is consistent with our research (shown in Figure 1 ). Previous studies have shown that DWOP can be seen in many fundus diseases, including hemoglobinopathy [ 15 ], retinal astrocytoma [ 7 ], white dot syndrome [ 7 ], HLA-B27 anterior middle uveitis [ 7 ], congenital retinal pigment epithelial hypertrophy [ 7 , 22 ], AIDS [ 19 ], Ebola [ 23 ], and choroidal osteoma [ 24 ]. The common feature of DWOP in OCT images is that the EZ is faded or has disappeared.…”

Section: Discussionmentioning

confidence: 99%

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Analysis of White and Dark without Pressure in a Young Myopic Group Based on Ultra-Wide Swept-Source Optical Coherence Tomography Angiography

Yu¹,

Luo²,

Zhang³

et al. 2022

JCM

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Purpose: This study aimed to investigate the incidence of white without pressure (WWOP) and dark without pressure (DWOP) in a young myopic group based on multimode imaging and to explore the quantitative changes in DWOP based on ultra-wide swept-source optical coherence tomography angiography (SS-OCTA). Methods: A total of 138 patients with high myopia (SE < −6.00 D) were recruited. Examinations, including indirect ophthalmoscope, ultra-wide color fundus photograph, and ultra-wide SS-OCTA, were conducted for each eye. A total of 50 of the 138 patients were selected for further analysis since their DWOP lesions in SS-OCTA could be well quantified. Results: The incidence rates of WWOP and DWOP in the young myopic group were 35.24% and 29.96%, respectively. The patients with a lower spherical equivalent (SE) showed a tendency to have a higher axial length (AL) and higher prevalence of WWOP. Multivariate regression analysis illustrated that a more serious SE and a longer AL were risk factors for both WWOP and DWOP. Eyes with DWOP lesions had lower vessel density (VD) in the whole retina (p < 0.001) and a deep vascular complex (DVC) (p < 0.001), and lower thickness of the outer retina (p < 0.001) compared with healthy counterparts. Conclusion: Ultra-wide SS-OCTA provided new insights into myopic-related peripheral retinal degenerations. DWOP was characterized by thinning of the outer retina and lower perfusion in DVC.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Analysis of White and Dark without Pressure in a Young Myopic Group Based on Ultra-Wide Swept-Source Optical Coherence Tomography Angiography

Yu¹,

Luo²,

Zhang³

et al. 2022

JCM

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“…14 However, cases of perilesional DWP enable an insight into their underlying aetiology, where the cause is known. While perilesional areas of DWP have been reported adjacent to non-infectious lesions such as congenital hypertrophy of the retinal pigment epithelium 15 , and choroidal osteomas 16 , they have also been associated with infectious aetiologies such as Ebola retinal lesions. 8 Over a 12-month observational period, following Ebola virus disease (EVD) infection, areas of DWP were observed to retract back towards EVD lesions in some cases, while in other examples were observed to both simultaneously expand and contract at opposing DWP margins suggesting the presence of an unknown prolonged intraretinal stimulus post-infection.…”

Section: Discussionmentioning

confidence: 99%

Ocular Toxoplasmosis Associated Dark Without Pressure

Steptoe

Guly

Dick

2022

Ocular Immunology and Inflammation

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“…8 The etiology is unclear, but it was suggested to represent a congenital, benign, and incidental lesion that requires no further evaluations. [8][9][10][11][12][13] Two cohort studies on Ebola virus survivors reported dark without pressure lesions in some patients, which may be related to viral disease. 14,15 Herein, we report multimodal imaging ndings in pediatric retinal vasculitis patients who demonstrated DWP.…”

Section: Introductionmentioning

confidence: 99%

Multimodal Imaging of Dark Without Pressure Lesions in Pediatric Retinal Vasculitis

Nguyen,

Yasar,

Ghoraba

et al. 2024

Preprint

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Purpose: A unique form of retinopathy-plausibly dark without pressure (DWP) was identified during the management of pediatric patients with retinal vasculitis (RV) and described in the index case series. Methods:Forty-three consecutive pediatric uveitis patients presented to tertiary care-unit were evaluated. We assessed DWP-like lesions in pediatric patients with RV. Wide angle fundus photographs (WAFP), fundus autofluorescence (FAF), and optical coherence tomography (OCT) images were analyzed to identify potential retinopathy. Incidence of DWP in pediatric RV patients was also analyzed. WAFP were evaluated using image-J software to measure retinopathy area (RA). Results:Twenty-six of 43 patients were diagnosed with RV and were treated. Retinopathy was detected in 20 patients (30 eyes/76.9%) during treatment. Mean age was 12.8±3.36 years; 40% were female. On WAFP, the lesions appeared as dark areas that were diffuse, mid-peripheral or peripheral. All 20 patients (30 eyes) showed hypo-autofluorescence on FAF at the same locations as the WAFP. Twelve patients (17 eyes) who had OCT images of the RA demonstrated ellipsoid zone disruption. Progression of the retinopathy overtime was analyzed in 28 eyes; all eyes showed improvement of RV with therapy. Mean RA significantly decreased from 394.67 mm2 (time of retinopathy detection) to 365.88 mm2 (last follow-up) (p=0.03). Conclusions:Pediatric RV may be associated with a retinopathy pattern described as DWP previously. Improvement in the RA may be related to improvement of disease activity, but further studies are needed to understand the underlying pathophysiology. Such findings might serve as a marker of previous/ongoing RV in pediatric patients.

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Dark Without Pressure in a Case of Choroidal Osteoma

Cited by 5 publications

References 9 publications

Analysis of White and Dark without Pressure in a Young Myopic Group Based on Ultra-Wide Swept-Source Optical Coherence Tomography Angiography

Analysis of White and Dark without Pressure in a Young Myopic Group Based on Ultra-Wide Swept-Source Optical Coherence Tomography Angiography

Ocular Toxoplasmosis Associated Dark Without Pressure

Multimodal Imaging of Dark Without Pressure Lesions in Pediatric Retinal Vasculitis

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