Darwin 200: Let's make a mammoth

Nicholls, Henry

doi:10.1038/456310a

Cited by 22 publications

(15 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Recently a publication in one of the world's premier journals proposed a complex biomedical technique where elephant eggs would have to be transplanted into mice to grow mature follicles in a tissue environment where the mouse's pituitary gland should be removed and subjected to an elephant hormonal cycle by external hormone therapy. 3 The authors had not consulted a clinician to identify that the whole step could have been replaced by a feasible, well-established and less demanding surgical laparoscopic technique that is used in modern bariatric surgery. 4 There are also many examples where clinicians have not been recognized despite contributing to discoveries that were subsequently awarded a Nobel Prize.…”

mentioning

confidence: 99%

Nobel Prizes in Medicine: are clinicians out of fashion?

et al. 2011

View full text Add to dashboard Cite

mentioning

confidence: 99%

Nobel Prizes in Medicine: are clinicians out of fashion?

et al. 2011

View full text Add to dashboard Cite

“…'If you want to bring a species back to life, the mammoth would be almost as dramatic as a dinosaur' (Nicholls 2008). Cloning extinct species would be a dramatic event as it brings back into existence something thought to be permanently lost.…”

Section: Extinct Cloning: Woolly Mammoth (Mammuthus Primigenius)mentioning

confidence: 99%

“…The ideal surrogate and egg donor for mammoths is the Asian (also called Indian) elephant (Nicholls 2008), which is an endangered species. The endangered status of Asian elephants makes it 'completely unethical to use these animals for cloning a mammoth' (Pina-Aguilar et al 2009).…”

Section: Negative Ethical Aspects Of Cloning Mammothsmentioning

confidence: 99%

“…The endangered status of Asian elephants makes it 'completely unethical to use these animals for cloning a mammoth' (Pina-Aguilar et al 2009). The cost on the elephants is too great; the individual elephants could develop ovarian tumors or be otherwise harmed through harvesting eggs or through the surrogate process, where mammoth fetuses may be unsuited to the uterus of the elephant (Nicholls 2008) and may do her harm. The potential death or harm to the elephants is too great a cost.…”

Section: Negative Ethical Aspects Of Cloning Mammothsmentioning

confidence: 99%

See 1 more Smart Citation

Resuscitation and resurrection: The ethics of cloning cheetahs, mammoths, and Neanderthals

Cottrell

Jensen

Peck

2014

Life Sci Soc Policy

View full text Add to dashboard Cite

Recent events and advances address the possibility of cloning endangered and extinct species. The ethics of these types of cloning have special considerations, uniquely different from the types of cloning commonly practiced. Cloning of cheetahs (and other endangered or vulnerable species) may be ethically appropriate, given certain constraints. However, the ethics of cloning extinct species varies; for example, cloning mammoths and Neanderthals is more ethically problematic than conservation cloning, and requires more attention. Cloning Neanderthals in particular is likely unethical and such a project should not be undertaken. It is important to discuss and plan for the constraints necessary to mitigate the harms of conservation and extinct cloning, and it is imperative that scientific and public discourse enlighten and guide actions in the sphere of cloning.

show abstract

“…For the revival of the woolly mammoth, for instance, the discovery of well-preserved and uncontaminated DNA, or ancient DNA (aDNA for short) in the paleobiological vocabulary, would be necessary. The technical details and hurdles of implementing genome engineering are communicated in many works (Shapiro 2015;Nicholls 2008). More critically, no matter what technique is employed, the resulting individuals might not be perfect or pure instances of the species.…”

Section: Three Phases Of De-extinctionmentioning

confidence: 99%

De-extinct species as wildlife

Oksanen

Vuorisalo

2017

FJHAS

View full text Add to dashboard Cite

The concept of wildlife embodies two sources of controversy regarding de-extinct animals. First, the multifaceted dependence of these animals on humans; and second, the property rights to de-extinct animals. Both provide reasons for not counting them as wildlife. A subsequent question is, however, whether we should maintain this divide or allow the boundaries to blur. If we aim to maintain it, we end up trying to stop a process that is evolving rapidly and difficult to curb by legal means. If we relinquish these boundaries, we give up customary cultural models and related cultural practices. In biology, the divide between domestic and wild species is usually considered arbitrary and the degree of synanthropy (degree of association with humans) to present a continuum. Still, wildlife is normally defined through the notion of domestication: those animals that are not domesticated are wildlife. Deextinction turns the setting upside down: the de-extinct animals would normally be classified as domesticated, since they are generated by human action and could be owned as private property, but the problem is that they are not intended as domestic -de-extinct animals are ultimately created to be wildlife. Thus the concept of wildlife calls for refinement so as to allow their inclusion. We present a classification of animal species based both on their degree of synanthropy and the complex ownership issues. It appears that de-extinct species would probably initially represent species with a low synanthropy index but a high need for human care, but might later evolve into "real" wildlife in the strict sense of the term.

show abstract

Darwin 200: Let's make a mammoth

Cited by 22 publications

References 11 publications

Nobel Prizes in Medicine: are clinicians out of fashion?

Nobel Prizes in Medicine: are clinicians out of fashion?

Resuscitation and resurrection: The ethics of cloning cheetahs, mammoths, and Neanderthals

De-extinct species as wildlife

Contact Info

Product

Resources

About