Darzens Condensation

Abstract

The synthesis of glycidic esters from the condensation between aldehydes or ketones and esters of α‐halo‐carboxylic acids is known as Darzens condensation. This type of condensation has also been extended to α‐halogenated nitriles, sulfoxides, sulfones, sulfoximines, carboxylic amides, etc. The reaction between carbonyl compounds and α‐halogenated ketimine is also referred to as the aza ‐Darzens reaction. This reaction has been modified to occur in the solid‐liquid two‐phase system using a solid base and catalyst at temperatures higher than 100°C.