Das Bild der menschlichen Nasenschleimhaut im Laufe des fetalen und postnatalen Lebens

Wustrow, F

doi:10.1007/bf02103974

Cited by 6 publications

(4 citation statements)

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“…Potential micromorphological changes await further investigation. Zaritzky (1936) and Wustrow (1958) described age-related atrophy of the nasal mucosa due to degeneration of the mucous membrane and connective tissue.…”

Section: Discussionmentioning

confidence: 98%

“…Dryness of the nose in the elderly Macroscopically, one of the main age-related changes of the inner nose in the elderly is atrophy of the mucosa and of the subepithelial connective tissue (Wustrow 1958).…”

Section: High Incidence Of Squamous Metaplasiamentioning

confidence: 99%

“…The surface of the epithelial lining of the turbinates becomes gibbous during adolescence (Zaritzky 1936). The inner nose of elderly people was characterised by atrophy of the mucosa, submucosal glands, the cavernous tissue and the bones of the turbinates (Zaritzky 1936;Wustrow 1958;Janzen 1986) responsible for a decrease of nasal resistance with higher age (Eccles 2000). While Hollender (1944) found no definite connection between age and type of the epithelium, Zaritzky (1936) describes squamous metaplasia sometimes even with keratinisation in people older than 40 years.…”

Section: Introductionmentioning

confidence: 95%

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Histological evaluation of age-related changes in human respiratory mucosa of the middle turbinate

Schrödter

Biermann

Halata

2003

Anatomy and Embryology

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Though the lining of the healthy human nose is subject of numerous investigations, age-related changes have attracted little attention. Furthermore, varying sampling sites complicate the evaluation of the available information. Reference is needed for evaluation of abnormal conditions, e.g. in persons with sleep apnea. Biopsy samples from the middle turbinate of 40 healthy humans aged 5 to 75 years were examined. Tissue samples were fixed immediately in glutaraldehyde and embedded in Epon for semi-thin sectioning and blind histological evaluation. In all age groups, patchy arrangement of different epithelial types were found. Ciliated epithelium decrease with age. Stratified and atrophic epithelial types show striking changes. Thin atrophic epithelium with conspicuously thickened basement membranes is only seen above the age of 40 years and is frequently found in older subjects. Stratified epithelial types initially increase with age, but decrease above 50 years. In the middle aged group (26 to 50 years) we found a remarkably high amount of squamous metaplasia, resulting in overall thicker epithelium becoming thinner in older subjects. In contrast, basement membranes are thinnest in the middle aged group. In conclusion, evaluating the histology of nasal respiratory epithelium must take pronounced age-related physiological changes into account.

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Section: Discussionmentioning

confidence: 98%

Section: High Incidence Of Squamous Metaplasiamentioning

confidence: 99%

Section: Introductionmentioning

confidence: 95%

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Histological evaluation of age-related changes in human respiratory mucosa of the middle turbinate

Schrödter

Biermann

Halata

2003

Anatomy and Embryology

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“…Nasal resistance is at a maximum in infants. Until the age of 16–18 years, resistance decline to an adult value and shows only a slow decline with increasing age [8]. Further decline of resistance seems to depend on atrophy of the mucosa, the submucosal glands, the cavernous tissue and the turbinate bones [9,10].…”

Section: Discussionmentioning

confidence: 99%

Risk factors for nasal bleeding in patients undergoing transnasal gastrointestinal endoscopy

Mieda

Miyashita

Osawa

et al. 2018

The Kaohsiung J of Med Scie

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Transnasal endoscopy is widely used in screening for upper gastrointestinal lesions because of less associated pain. Nasal bleeding is the most severe adverse effect, but specific risk factors have not been identified. The aim of this study is to identify risk factors for nasal bleeding during transnasal endoscopy. Nasal bleeding occurred in 160/3035 (5.3%) of patients undergoing transnasal endoscopy as part of health checkups. Patient data were retrospectively evaluated including anthropometric, medical, and life-style parameters with multiple logistic regression analysis. Multiple logistic regression revealed that nasal bleeding was significantly associated with age in decades [odds ratio/10 years 0.78, 95% confidence interval (CI) 0.63-0.97, p = 0.027], female gender (2.15, 95% CI 1.48-3.12, p < 0.001), a history of previous upper gastrointestinal endoscopy (0.55, 95% CI 0.36-0.82, p = 0.004), and chronic/allergic rhinitis (0.60, 95% CI 0.36-0.98, p = 0.043). Other factors including the use of antiplatelet and/or anticoagulant drugs were not significantly associated with nasal bleeding. Female and young patients are significantly associated with an increased risk of bleeding from transnasal endoscopy, but antiplatelet and/or anticoagulant medications and a history of chronic/allergic rhinitis may not be associated.

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Die Erkrankungen der Nase und ihrer Nebenhöhlen im Kindesalter

Legler¹

1968

Pädiatrische Grenzgebiete Augen · Ohren · Zähne · Haut

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Das Bild der menschlichen Nasenschleimhaut im Laufe des fetalen und postnatalen Lebens

Cited by 6 publications

References 0 publications

Histological evaluation of age-related changes in human respiratory mucosa of the middle turbinate

Histological evaluation of age-related changes in human respiratory mucosa of the middle turbinate

Risk factors for nasal bleeding in patients undergoing transnasal gastrointestinal endoscopy

Die Erkrankungen der Nase und ihrer Nebenhöhlen im Kindesalter

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