Das klinische Bild und die pathologischen Veränderungen eines Falles von schwerem subkortikalen Markabbau auf arteriosklerotischer Grundlage (Encephalopathia subcorticalis chronica, Binswanger)

Sudanophilic Diffuse Sclerosis ("Schilder's Disease") with Ictal Onset

“…The ictal onset in a man of this age had naturally in life suggested the presence of a cerebrovascular lesion, and when the destruction of white matter was noted the diagnosis of Binswanger's (1894) disease was considered. The finding of two disordered transcortical arterioles in the occipital lobes with softening of the contiguous grey matter lent some support to this suggestion, but a more detailed study failed to demonstrate any of the thickening of the arterioles in the white matter which has been noted by those who have reported such cases (Nissl, 1920;Girunthal, 1929;Farnell and Globus, 1932;Davison, 1942;and Pilleri and Risso, 1959). Neumann (1947) is of the opinion that some cases of reported Binswanger's disease may be no more than instances of Schilder's disease occuring in arteriosclerotic subjects.…”

Binswanger's disease: clinical and computed tomography neuroradiological study of seven cases

“…9 The psychotic and affective nature of this disease is also well illustrated in a case reported by Pilleri and Risso. 10 A woman aged 58 years was brought to a psychiatric hospital because of a slowly developing persistent delusion of persecution: she claimed that someone was trying to stab or poison her, or set her house on fire. She was extremely uneasy and restless, and 2 weeks before seeking medical help had tried to hang herself from a window.…”

Vascular Dementia

“…Some authors stress ischemia as the main pathophysiological process, not unlike MID [88,93] or other vascular forms of subcorti cal dementia [99]. Others consider vascular derange ments as secondary phenomena caused by a cerebral edema brought about by hypertension as the main factor [85, [105][106][107][108]. Periventricular watershed infarctions were attributed to transient cardiac failures or systemic hypotension [88,109].…”