Das Mikrobiom – die unplanbare Größe zukünftiger Therapien

Abstract

The microbiome is defined as the total of cellular microorganisms of baczerial, viral or e. g., parasite origin living on the surface of a body. Within the anatomical areas of otorhinolaryngology, a significant divergence and variance can be demonstrated. For ear, nose, throat, larynx and cutis different interactions of microbiome and common factors like age, diet and live style factors (e. g., smoking) have been detected in recent years. Besides, new insights hint at a passible pathognomic role of the microbiome towards diseases in the ENT area. This review article resumes the present findings of this rapidly devloping scientific area.

Einfluss von Konservierungsmitteln in Topika auf die kutane Mikrobiota

“…Das zur Sequenzierung verwendete PCR-Produkt wird durch spezifische Primer erzeugt, die an die hochkonservierten Regionen in unmittelbarer Nachbarschaft der variablen Regionen des 16S-rRNA-Gens der Bakterien binden. Anschließend wird das generierte Amplifikat sequenziert, und die dabei ermittelten Sequenzvarianten werden durch bioinformatische Analysen mit 16S-rRNA-Gen-Sequenzen bekannter Bakterien aus Datenbanken verglichen und taxonomisch klassifiziert [12]. Probleme dieser Analysen liegen in der Auswahl der variablen Regionen sowie im Umstand, dass die Methodik und das Material der Probennahme sehr fehleranfällig sind, begründet [13,14].…”

The Relevance of the Bacterial Microbiome, Archaeome and Mycobiome in Pediatric Asthma and Respiratory Disorders

“…The connection of the human microbiome to the pathogenesis of diseases has gained increasing interest over many years [9]. The microbiome is defined as the total organisms, including commensalistic and parasitic cellular microorganisms, as well as viruses that inhabit the body's surfaces [35]. The upper respiratory tract with the naso-and oropharynx in the sagittal plane.…”

Effects of squamous cell carcinoma and smoking status on oropharyngeal and laryngeal microbial communities

“…The human body is colonized by complex communities of microorganisms which interact closely with the host to modulate almost any aspect of the host physiological functions ranging from food digestion to immune homeostasis. 6 Various pathological disorders such as inflammatory bowel disease or cardiovascular disease have been linked with an imbalance or dysbiosis of the microbiota. 7,8 Dysbiosis was also observed in different kinds of cancer and as example colorectal cancer is usually characterized by an increased prevalence of members of the genera Fusobacterium, Porphyromonas, and Peptostreptococcus among others.…”

“…The human body is colonized by complex communities of microorganisms which interact closely with the host to modulate almost any aspect of the host physiological functions ranging from food digestion to immune homeostasis 6 . Various pathological disorders such as inflammatory bowel disease or cardiovascular disease have been linked with an imbalance or dysbiosis of the microbiota 7,8 .…”