Das Multi Center Database Project (MCDBP)

Kempler, Péter; Kowatsch, E.; Haid, A.; Bauer, Ch.; Steindorfer, P.

doi:10.1046/j.1563-2563.2001.01164.x

Cited by 12 publications

(8 citation statements)

References 4 publications

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“…Data from all patients treated with sentinel node biopsy in nine institutions in Austria were collected in a central database (9). Patients were eligible for sentinel node biopsy if they fulfilled the criteria described previously (14).…”

Section: Methodsmentioning

confidence: 99%

Axillary Recurrence after Sentinel Node Biopsy

Roka¹,

Kempler²,

Heck³

et al. 2002

European Surg

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Summary: Background: Sentinel lymph node biopsy seems to be a promising new method for determining axillary status in breast cancer. The method helps to reduce morbidity, and an increased number of micrometastases are detected in the sentinel nodes by which patients with a less favourable outcome are identified. However, no long‐term follow‐up data is available.  Methods: Data from 1567 breast cancer patients treated at nine institutions in Austria were collected in a centrally reviewed database. Included in this study were 383 patients with a negative sentinel node biopsy who were treated without axillary dissection. The median follow‐up was 19.5 months.  Results: Sentinel node biopsy was performed using blue dye (21.2 %), radiocolloid (24 %) or the combination of both methods (54.8 %).Two axillary recurrences were observed. Both patients developed distant disease synchronously or metachronously. Primary tumours of both patients showed high nuclear grading and negative hormone receptor status. Tumour size at primary diagnosis was 12 mm and 22 mm, respectively.  Conclusions: The current results of sentinel node biopsy seem to confirm the accuracy of the method. There are only sporadic reports in the literature on axillary recurrence after sentinel node biopsy. The risk of treatment failure after sentinel node biopsy can only be determined after the completion of prospective randomized trials. Therefore, sentinel node biopsy should be performed within therapeutic concepts with quality control.

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Section: Methodsmentioning

confidence: 99%

Axillary Recurrence after Sentinel Node Biopsy

Roka¹,

Kempler²,

Heck³

et al. 2002

European Surg

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“…A total of 2502 consecutive women with primary breast cancer, in whom a SLN procedure was performed, were registered by the multi-centre database project (MCDBP) (Konstantiniuk et al, 2001). Patient data from 12 participating departments of the Austrian Sentinel Node Biopsy Study Group were collected prospectively from 1999 onwards, but data from some centres were obtained retrospectively from 1996 onwards.…”

Section: Patients and Data Collectionmentioning

confidence: 99%

The impact of preoperative breast biopsy on the risk of sentinel lymph node metastases: analysis of 2502 cases from the Austrian sentinel node biopsy study group

et al. 2004

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Preoperative breast biopsy might cause disaggregation of tumour cells and tumour cell spread. The purpose of this study was to investigate the impact of preoperative biopsy on the rate of metastases to the sentinel lymph node (SLN) of patients with primary breast cancer. We report the results of 2502 patients with primary breast cancer, who were operated, and a sentinel node biopsy was performed. The association of preoperative biopsy with the risk of SLN metastases was examined by regression analyses and tested for possible confounding well-known factors for axillary node metastases. In all, 1890 patients were available for final analyses; 1048 (55.4%) patients had a preoperative diagnosis performed by fine-needle aspiration or core biopsy; 641 (33.9%) patients had a positive SLN when conventional H&E and IHC staining was performed. Patients with preoperative breast biopsy showed a 1.37 times (95% CI, 1.13 -1.66) increased risk of SLN metastases on univariate analysis, but this result was not persistent when analysis was adjusted for other relevant factors for axillary node metastases, OR 1.09 (95% CI, 0.85 -1.40). In addition, subgroup analyses of the risk for occult micro metastases to the SLN (detected by IHC only) on H&E-negative cases also showed no increased risk associated with preoperative biopsy, OR 1.07 (95% CI, 0.69 -1.65). The conclusion, based on the present data, is that preoperative breast biopsy does not cause artificial tumour cell spread to the SLN, with possible negative impact on the prognosis of breast cancer.

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“…Die Datenerfassung und -auswertung erfolgte mit einer von der Österreichischen Arbeitsgruppe "Sentinel Node Biopsy" der ABCSG (Austrian Breast-and Colorectal Cancer Study Group) erstellten Microsoft Access Datenbank: Multi Center Database Project [20]. Auf eine Axilladissektion nach SNB wurde bei124 Patienten verzichtet, davon bei 6 mit besiedelten SN (2-mal bei Makrometastasen, 4-mal bei Mikrometastasen) aufgrund hohen Alters und des ausdrücklichen Patientenwunsches.…”

Section: Nachbeobachtungszeit Und Datenerfassungunclassified

“…Die laufende Dokumentation in einer geeigneten Datenbank, die kritische Überprüfung der eigenen Ergebnisse und der gesamten Institution sowie der fortlaufende Vergleich mit jenen der Literatur erscheinen uns zur Qualitätskontrolle unabdingbar und entsprechen auch internationalen Empfehlungen [2,22,27,29]. Das Multicenter Data Base Project der Österreichischen Arbeitsgruppe "Sentinel Node Biopsy" erwies sich dabei sehr hilfreich und benutzerfreundlich [20].…”

Section: Diskussionunclassified

Klinische Wertigkeit und zuk�nftige Aspekte der "Sentinel Node Biopsy" beim Mammakarzinom

et al. 2003

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Our experience shows SNB to be reliable and accurate for axillary staging in breast cancer patients. Morbidity after SNB alone was low. Conclusive data on the local recurrence rate are not yet available. Under certain conditions, SNB appears to have future clinical potential, even in patients with PC and MC, which must be confirmed in further multicentric studies. In the meantime, this method has attained definite value in the surgical therapy of breast cancer patients.

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Das Multi Center Database Project (MCDBP)

Cited by 12 publications

References 4 publications

Axillary Recurrence after Sentinel Node Biopsy

Axillary Recurrence after Sentinel Node Biopsy

The impact of preoperative breast biopsy on the risk of sentinel lymph node metastases: analysis of 2502 cases from the Austrian sentinel node biopsy study group

Klinische Wertigkeit und zuk�nftige Aspekte der "Sentinel Node Biopsy" beim Mammakarzinom

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