Das Pigment der Melanosis coli und seine chemische Darstellung aus dem Organ

Melanosis of the appendix: common in the paediatric age group

“…In no case was significant melanosis identified distally without proximal involvement. This pattern of distribution of melanosis of the appendix is similar to that seen in the study by Rutty et al ., 6 confirming Pick's original observation 11 …”

“…This pattern of distribution of melanosis of the appendix is similar to that seen in the study by Rutty et al, 6 con®rming Pick's original observation. 11 A study that looked at the incidence of melanosis of the colon in 200 consecutive autopsy cases 12 showed microscopic evidence in 59.5% of cases, ranging from 30% in the 20±54 years age group, up to 71.4% in the over 75 years group. This was shown to be more common in the right side of the colon.…”

Melanosis of the appendix: prevalence, distribution and review of the pathogenesis of 47 cases

“…Both Pick in 1930 19 and Stewart in 1931 12 reported the frequent occurrence of melanosis within the appendix at autopsy although to date only one other series by Derizhanova has attempted to quantify its occurrence 13 . In our consecutive series of 636 appendices removed at operation in patients 40 years or older we found 47 cases of melanosis (7.4%).…”

Review article: anthranoid laxatives and their potential carcinogenic effects

“…Some authors claim that the pigmentation to be most pronounced in the rectum and decreasing toward the caecum, stopping abruptly at the ileocaecal valve, 59 whereas others have stated that pseudomelanosis coli is most common in the proximal colon and much rarer in the distal parts 60 . Originally, the pigment was considered to be melanin or a melanin‐like substance 61 , 62 and therefore the name melanosis coli was introduced. This was later changed into pseudomelanosis coli as the pigment proved to be more characteristic, both histochemically and ultrastructurally, for lipofuscin 50 , .…”