Das Potenzial von RiPPs in medizinisch-biotechnologischen Anwendungen

Abstract

Ribosomally synthesized and post-translationally modified proteins (RiPPs) are an interesting natural product superfamily. Their underlying biosynthetic principles, where recognition sites are strictly separated from the regions that are modified in the substrate, make them interesting for utilization in medicinal and biotechnological applications. Here, the promiscuity of RiPP biosynthetic enzymes will be described for examples from the lasso and lanthipeptide subfamilies and current developments as well as future directions in this field will be discussed.