Das Problem der Knorpelmineralisation am Beispiel des verkalkenden freien Gelenkk�rpers

Biological Calcification

“…On the other hand, the frequent report that matrix vesicles are located around degenerating chondrocytes or can be found collected in groups reminiscent of chondrocyte lacunae suggests that they may also derive from the degeneration and fragmentation of chondrocytes (Bonucci 1970aDearden 1974;Bonucci and Dearden 1976;Takagi et al 1979;Akisaka and Shigenaga 1983;Akisaka and Gay 1985a;Reinholt et al 1982Reinholt et al , 1984. This process has long been known as "Verdämmern der Zellen" ('vanishing of cells' ;Schaffer 1930) and is now thought to be a possible expression of cellular apoptosis (Kim 1976;Kardos and Hubbard 1982;Lotz et al 1999), a process that has been induced experimentally in articular cartilage ) and that seems to characterize the terminal phase of hypertrophic chondrocytes (Rauterberg and Becker 1970;Kim 1995;Zenmyo et al 1996;Gibson et al 1997;Szuwart et al 1998;Magne et al 2003). However, as reported above, the composition of apoptotic bodies differs to some extent from that of matrix vesicles .…”