Das serologische Protein S100B

Abstract

Serological protein S100B measurement may be helpful as a screening test to identify patients with higher risk of traumatic brain injury for further diagnostic assessment.

Imaging minor head injury (MHI) in emergency radiology: MRI highlights additional intracranial findings after measurement of trauma biomarker S-100B in patients with normal CCT

“…A recent metaanalysis including .2000 patients showed a combined sensitivity of 94 % (95% CI, 88-98%) and a combined specificity of 44% (95% CI, 30-58%) with diagnostic odds ratio of 10.3 (95% CI, 4.2-24.9%). 10 Muller et al 31 concluded in a consensus paper that the biomarker can triage patients to CCT, again with a high NPV and decrease the large number of normal CCT and set free capacities of the emergency rooms.…”

“…According to a recent meta-analysis, combined sensitivity can reach up to 94% [95% confidence interval (CI), 88-98%] and a combined specificity is only 44% (95% CI, 30-58%). [10][11][12] Some reports have also shown raised concentrations of the biomarker in patients with non-traumatic parenchymal lesions such as infections 13 and extracranial injuries. 14 As MHI is very common and imaging is associated with significant costs and radiation exposure, an additional risk parameter could be of great value to stratify the patients at risk for TBI to undergo CCT.…”