Das seröse Cystadenom des Pankreas

Nagel, Michael; Dobrowolski, F.; Bunk, A.; Saeger, H. D.

doi:10.1007/s001040050830

Cited by 7 publications

(7 citation statements)

References 17 publications

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“…The review of series of five and more serous cystic neoplasms [7, 10, 21, 25, 26, 27, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49]showed that serous cystadenoma of the pancreas presents at an earlier age (mean 61 years) than serous cystadenocarcinoma (mean 66 years; table 2 [5, 6, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28]). This difference was almost statistically significant (p = 0.056).…”

Section: Resultsmentioning

confidence: 99%

Risk of Malignancy in Serous Cystic Neoplasms of the Pancreas

et al. 2003

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Background: In contrast to mucinous cystic neoplasms of the pancreas, which are known to have considerable malignant potential, the serous variant is generally thought to be benign. There are, however, several reports of malignancy in serous cystic neoplasms of the pancreas. Aims: To assess the risk of malignancy of serous cystic tumors of the pancreas and to investigate specific clinical and histological features. Methods: Clinical and pathological characteristics of benign and malignant serous cystic neoplasms of the pancreas were investigated by a review of the literature and documented by a case of a serous cystadenocarcinoma and immunohistochemical analysis of a series of serous cystadenomas. Reviewing the literature prevalence, age and sex distribution of serous cystic neoplasms were analyzed. Results: The prevalence of cancer among serous cystic neoplasms reported since 1989 was 3%. Serous cystadenoma of the pancreas present at an earlier age (61 years) than serous cystadenocarcinoma (66 years; p = 0.056) and are symptomatic in the majority of patients.Pathological examination of the primary tumor was not able to distinguish cystadenoma from cystadenocarcinoma in 38% of cases. In 25% the diagnosis of cancer was established only after growth of metachronous metastases. In the present case, nuclear atypia, papillary structures, proliferation marker Ki-67 and p53 protein were increased in the primary tumor and/or metachronous metastasis. Conclusion: Serous cystic neoplasms of the pancreas do have malignant potential with a risk of malignancy of 3% and should be surgically treated if the operative risk is acceptable. Routine analysis of genetic and proliferation markers may improve diagnosis of malignancy in these tumors.

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Section: Resultsmentioning

confidence: 99%

Risk of Malignancy in Serous Cystic Neoplasms of the Pancreas

et al. 2003

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“…Although only 23 cases of SOAs have been reported in the literature, [3][4][5][6][7][8] SOAs showed 10% of serous cyst adenoma by advances in imaging techniques. 9 In general, SOAs require surgical resection.…”

Section: Discussionmentioning

confidence: 99%

“…2 To date, only 23 cases of SOA have been reported. [3][4][5][6][7][8] Although the increasing number of scientific Offprint requests to: K. Sakata Received: February 6, 2002 / Accepted: December 18, 2002 previously. Angiography revealed stretching of the vessels adjacent to the cyst without encasement or staining (Fig.…”

Section: Introductionmentioning

confidence: 99%

A serous oligocystic adenoma of the head of the pancreas successfully treated by dome resection and chemocautery: a new approach to serous oligocystic adenoma

Sakata

Maeda

Harada

et al. 2003

Journal of Hepato-Biliary-Pancreatic Surgery

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Serous oligocystic adenoma (SOA) is an extremely rare benign tumor and ill-demarcated large cyst. We report a case of pancreatic SOA. During abdominal ultrasonography (US) for a routine health examination and computed tomography (CT), a 69-year-old woman was found to have a 9-cm unilocular cyst located in the head of her pancreas. After a 2-year follow up, the cyst was seen to increase in size. The results of US, CT, magnetic resonance imaging, endoscopic retrograde cholangiopancreatography (ERCP), and angiography led to suspicion of a benign or low grade malignancy cystadenoma of the pancreas adjacent to the peripheral organs. Fluid analysis and frozen section pathological studies revealed a serous oligocystic adenoma with no malignancy. Dome resection, chemocautery, and omental filling were performed, and the postoperative course was uneventful. SOAs are difficult to diagnose without surgery. When the cyst exists in the head of the pancreas, adjacent to the biliary tract, portal system, or visceral vessels, it is also difficult to perform complete resection without the threat of morbidity or mortality. We have developed a new approach to SOA diagnosis and treatment that involves minimally invasive procedures.

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“…50 mm) zur Entartung und imponiert sonographisch durch große Zysten. Seltener ist das mikrozystische seröse Pankreasadenom mit seiner wabenartigen Binnenstruktur, das sehr selten entartet [145,[166][167][168][169][170][171][172][173]. Farbduplexsonographisch ist es stärker vaskularisiert und zeigt typischerweise eine zuführende Arterie (wegen der Analogie auch "FNH [fokal noduläre Hyperplasie] des Pankreas" genannt; Abbildung 5).…”

Section: Pankreastumorenunclassified

Aktueller Stand der Sonographie in der Gastroenterologie

Nuernberg¹,

Ignee

Dietrich

2007

Med Klin

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GALLBLADDER: Ultrasound has become widely accepted for the diagnosis of gallbladder disease. Sensitivity for cholecystolithiasis is approximately 100%. Cholezystitis including its acute and chronic complications is also a domain of ultrasound techniques. An obstruction of the bile ducts and its localization are easily recognized. Clarifying the etiology is yet another question far more difficult to answer. Ultrasound contrast agents have proven to be useful for clarification of biliary tumors. Gallbladder polyps are well detectable. Adenomas of > 1 cm are an indication for surgery, the detection of a vessel at the polyps' base by color duplex ultrasound is helpful. Gallbladder carcinomas as a disease of the older age with few early symptoms are usually detected at a late stage when the liver is already infiltrated. BILE DUCT SYSTEM: Even with the most modern equipment the sensitivity for choledocholithiasis is still largely dependent on the examiner's expertise und differs between 25% and 100%. Endosonography is more efficient (94-100%). Primary sclerosing cholangitis shows bile duct dilation like "a string of pearls" and typical perihepatic lymph node enlargement. Differentiation from early cholangiocarcinoma is difficult. PANCREAS: In diagnostic imaging of the pancreas ultrasound stands at the beginning of a diagnostic cascade. In contrast to other competing examinations it can be repeated at any time and without X-ray exposure. The informative value, though, is largely dependent on the examiner's expertise. Usually, a CT scan is additionally performed when ultrasound examination is incomplete or limited through examination condition or if doubts on diagnostic accuracy arise. In cases of acute pancreatitis, especially the assessment and follow-up of complications (exudation, necrosis, pseudocysts, vascular complications, and obstructive effects) are precious. Ductal adenocarcinoma seems to be less vascularized in comparison to the surrounding tissue, while endocrine tumors and macro- and microcystic adenoma are rather hypervascularized.

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Das seröse Cystadenom des Pankreas

Abstract: Because of the difficulty in reliably differentiating benign and malignant lesions of the pancreas, we believe that cystic tumors of the pancreas should be resected.

Cited by 7 publications

References 17 publications

Risk of Malignancy in Serous Cystic Neoplasms of the Pancreas

Risk of Malignancy in Serous Cystic Neoplasms of the Pancreas

A serous oligocystic adenoma of the head of the pancreas successfully treated by dome resection and chemocautery: a new approach to serous oligocystic adenoma

Aktueller Stand der Sonographie in der Gastroenterologie

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