2024
DOI: 10.1002/ange.202317552
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Das Zöliakie‐Superantigen Oligomerisiert und Erhöht die Permeabilität in einem Enterozyten‐Zellmodell

Maria G. Herrera,
Maria J. Amundarain,
Philipp W. Dörfler
et al.

Abstract: Celiac disease (CeD) is an autoimmune disorder triggered by gluten proteins, affecting approximately 1% of the global population. The 33‐mer deamidated gliadin peptide (DGP) is a metabolically modified wheat‐gluten superantigen for CeD. Here, we demonstrate that the 33‐mer DGP spontaneously assembles into oligomers with a diameter of approximately 24 nm. The 33‐mer DGP oligomers present two main secondary structural motifs—a major polyproline II helix and a minor β‐sheet structure. Importantly, in the presence… Show more

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