Das Zusammenwirken von Rhodiola rosea (Eisenwurz) und Antidepressiva

Maniscalco, Ignazio; Toffol, Elda; Giupponi, Giancarlo; Conca, Andreas

doi:10.1007/s40211-014-0124-8

Cited by 15 publications

(8 citation statements)

References 7 publications

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“…Rhodiola can modulate hypothalamic-pituitary-adrenal (HPA) axis activity as well as that of several neurotransmitters [ 104 ]. Maniscalco et al recently reported the case of a 68-year-old female patient with recurrent moderate depressive disorder with somatic syndrome who developed vegetative syndrome, feelings of restlessness, and trembling since she began ingesting Rhodiola supplements in addition to paroxetine [ 107 ]. These symptoms may have been due to serotonergic syndrome [ 107 ]; therefore, it is possible that concomitant use of Rhodiola and selective SSRIs may lead to an excess of serotonin in the CNS and/or in peripheral nervous system with subsequent increased clinical risks.…”

Section: Interaction Between Weight-loss-related Herbal Products Amentioning

confidence: 99%

Adverse Psychiatric Effects Associated with Herbal Weight-Loss Products

Bersani

Coviello

Imperatori

et al. 2015

BioMed Research International

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Obesity and overeating are among the most prevalent health concerns worldwide and individuals are increasingly using performance and image-enhancing drugs (PIEDs) as an easy and fast way to control their weight. Among these, herbal weight-loss products (HWLPs) often attract users due to their health claims, assumed safety, easy availability, affordable price, extensive marketing, and the perceived lack of need for professional oversight. Reports suggest that certain HWLPs may lead to onset or exacerbation of psychiatric disturbances. Here we review the available evidence on psychiatric adverse effects of HWLPs due to their intrinsic toxicity and potential for interaction with psychiatric medications.

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Section: Interaction Between Weight-loss-related Herbal Products Amentioning

confidence: 99%

Adverse Psychiatric Effects Associated with Herbal Weight-Loss Products

Bersani

Coviello

Imperatori

et al. 2015

BioMed Research International

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“…In HDI case reports, some drug classes are over-represented. These classes include immunosuppressants [18,[34][35][36][37], anticancer drugs (ATC class L01, three cases, CR 4, 5, 10) [19,38,39]. This observation confirms that most cases are related to long-term conventional treatments and small therapeutic index drugs.…”

Section: Case Reportsmentioning

confidence: 55%

“…Among these cases, 12 mention CYP isoenzymes (CYP2C9, CYP1A2, CYP2D6, CYP3A4, CYP3A5). In only one case (CR 17), a pharmacodynamic interaction is mentioned with the addition of serotonin syndrome [37].…”

Section: Case Reportsmentioning

confidence: 99%

HDI Highlighter, The First Intelligent Tool to Screen the Literature on Herb–Drug Interactions

2022

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Herbal food supplements are commonly used and can be an important part of patient self-care. Like all other bio-active and therapeutic products, they have a benefit/risk balance. These products are not without adverse effects and potentially interact with other therapies. Educating patients and providing information for health professionals about the risk of herb-drug interactions is key. One of the purposes of the biomedical literature is to inform prescribers. Scientific literature accessible on databases such as PubMed is dense and careful reading is time consuming. We propose a reading aid tool named "HDI highlighter" to help readers to find key information in clinical studies and case reports describing herb-drug interactions. It uses natural language processing algorithms (artificial intelligence) with a pharmaceutical focus. Semantic relation extraction for herb-drug interactions from the biomedical literature are overexpressed using keywords. We have tested it to review 120 published articles over the last 10 years. In these articles, we have shown that case reports often involved long-term or semi-long-term treatments such as cancer or human immunodeficiency virus therapies, antiepileptic drugs, or central nervous system drugs. Similarly, these classes of drugs are more extensively targeted by clinical studies. Herb-drug interactions described in case reports are identified in medicinal, recreational, and alimentary uses. They also usually lack a rigorous description of the herb(s) involved. Typically, clinical studies provide a complete description of protocols and dosages, with a few exceptions explained by patients' needs. Clinical studies on herbs are nevertheless conducted on a limited number of patients. All these limitations make the interpretation of herb-drug interactions complicated, but the HDI highlighter provides a quick overview of the herb-drug interaction literature.

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“…One clinical case reported a young healthy woman who had a significant tachyarrhythmia whilst taking a combination of escitalopram and Rhodiola (McGovern & McDonnell, 2010). Moreover, one other clinical case reported a 68‐year‐old female patient, with recurrent moderate depressive disorder with somatic syndrome, who developed vegetative syndrome, restlessness feeling and trembling, since she began to ingest Rhodiola in addition to paroxetine (Maniscalco et al, 2015). Therefore, the risk of pharmacokinetic and pharmacodynamic interactions of this species with SSRIs must be assumed.…”

Section: Herb Interactions With Drugs Acting On the Cns And Pnsmentioning

confidence: 99%

Herb‐drug interactions: A short review on central and peripheral nervous system drugs

Bernardo,

Valentão

2024

Phytotherapy Research

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Herbal medicines are widely perceived as natural and safe remedies. However, their concomitant use with prescribed drugs is a common practice, often undertaken without full awareness of the potential risks and frequently without medical supervision. This practice introduces a tangible risk of herb‐drug interactions, which can manifest as a spectrum of consequences, ranging from acute, self‐limited reactions to unpredictable and potentially lethal scenarios. This review offers a comprehensive overview of herb‐drug interactions, with a specific focus on medications targeting the Central and Peripheral Nervous Systems. Our work draws upon a broad range of evidence, encompassing preclinical data, animal studies, and clinical case reports. We delve into the intricate pharmacodynamics and pharmacokinetics underpinning each interaction, elucidating the mechanisms through which these interactions occur. One pressing issue that emerges from this analysis is the need for updated guidelines and sustained pharmacovigilance efforts. The topic of herb‐drug interactions often escapes the attention of both consumers and healthcare professionals. To ensure patient safety and informed decision‐making, it is imperative that we address this knowledge gap and establish a framework for continued monitoring and education. In conclusion, the use of herbal remedies alongside conventional medications is a practice replete with potential hazards. This review not only underscores the real and significant risks associated with herb‐drug interactions but also underscores the necessity for greater awareness, research, and vigilant oversight in this often‐overlooked domain of healthcare.

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Das Zusammenwirken von Rhodiola rosea (Eisenwurz) und Antidepressiva

Cited by 15 publications

References 7 publications

Adverse Psychiatric Effects Associated with Herbal Weight-Loss Products

Adverse Psychiatric Effects Associated with Herbal Weight-Loss Products

HDI Highlighter, The First Intelligent Tool to Screen the Literature on Herb–Drug Interactions

Herb‐drug interactions: A short review on central and peripheral nervous system drugs

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