Dasatinib and PD-L1 inhibitors provoke toxicity and inhibit angiogenesis in the embryo

Al-Asmakh, Maha; Bawadi, Hiba; Hamdan, Munia M.; Gupta, Ishita; Kheraldine, Hadeel; Jabeen, Ayesha; Rizeq, Balsam; Moustafa, Ala‐Eddin Al

doi:10.1016/j.biopha.2020.111134

Cited by 10 publications

(8 citation statements)

References 51 publications

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“…Tumour angiogenesis plays an important role in tumour metastasis 27 . PD‐L1 inhibitors significantly inhibit angiogenesis in embryos 28 . TAM/M2 polarizes to TAM/M1 can inhibit VEGF expression and angiogenesis, and inhibition of angiogenesis can reshape TME so that promote the polarization of TAM/M2 to TAM/M1 29 .…”

Section: Discussionmentioning

confidence: 99%

“… 27 PD‐L1 inhibitors significantly inhibit angiogenesis in embryos. 28 TAM/M2 polarizes to TAM/M1 can inhibit VEGF expression and angiogenesis, and inhibition of angiogenesis can reshape TME so that promote the polarization of TAM/M2 to TAM/M1. 29 However, the role of PD‐L1 in TAM/M2 polarization‐induced malignant progression of NSCLC remains unclear.…”

Section: Discussionmentioning

confidence: 99%

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PD‐L1/p‐STAT3 promotes the progression of NSCLC cells by regulating TAM polarization

Zhang

Meng

et al. 2022

J Cellular Molecular Medi

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Lung cancer is the second most common cancer, and the most common cause of cancer death. 1 Lung cancer is divided into two groups small cell lung cancer (SCLC) and non-small cell lung cancer (NSCLC).NSCLC is more common than SCLC, accounting for about 85% of all lung cancer patients. 2 The clinical treatment of NSCLC includes surgical operation, radiotherapy, chemotherapy, molecular targeting therapy and neoadjuvant therapy. 3 However, traditional therapeutic methods still have shortcomings, such as large side effects, high recurrence rates and drug tolerance. Thus, the development of innovative approaches such as tumour immunotherapy may provide a new therapeutic strategy for the treatment of NSCLC.Tumour microenvironment (TME) is the survival condition of tumour cells. 4 Tumour-associated macrophages (TAMs) can be polarized into pro-inflammatory and anti-cancer M1 type (TAM/M1) or

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

PD‐L1/p‐STAT3 promotes the progression of NSCLC cells by regulating TAM polarization

Zhang

Meng

et al. 2022

J Cellular Molecular Medi

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“…Cette technique ne règle pas, de plus, les problèmes éthiques liés à l'utilisation de mammifères [23]. Peu de données sont disponibles concernant les effets de drogues ciblant le système immunitaire (immunomodulateurs ou inhibiteurs de points de contrôle immunitaire) dans le modèle de CAM [24]. Cependant, la cinétique de la maturation du système immunitaire chez l'embryon de poule et les différences et similitudes des systèmes immunitaires humain et aviaire sont connus [25].…”

Section: Un Modèle D'étude De L'efficacité Des Drogues Ciblant Le Sys...unclassified

L’embryon de poule

Sola

Caillot

2022

Med Sci (Paris)

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Le développement de drogues anti-cancéreuses à visée thérapeutique nécessite leur évaluation. Ces drogues candidates sont généralement testées in vitro, sur des lignées cellulaires ou sur des cellules isolées à partir de patients, et, in vivo, dans des modèles de xénogreffe chez la souris immunodéprimée. Depuis quelques années, les contraintes réglementaires (règle des 3R : réduire, raffiner, remplacer) imposent de mettre en place des modèles alternatifs qui se substituent aux modèles murins ou, au moins, en limitent l’utilisation. Parmi les modèles alternatifs proposés, la greffe sur membrane chorio-allantoïdienne d’embryon de poule semble performante. Elle permet de suivre et de quantifier la croissance tumorale et d’autres paramètres associés, comme la néo-angiogenèse, l’invasion et la migration tumorales. Elle permet aussi le criblage de drogues. Ce modèle semble également adapté à la médecine personnalisée en cancérologie. Nous présentons dans cette revue la technique et ses avantages.

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“…The vascular development of the CAM was examined after 24 and 48 h of exposure using a stereomicroscope and images were captured. Quantification of the total number of junctions, length of blood vessels, and vessels area of exposed CAM was performed using the AngioTool Software 0.6a and compared to unexposed areas [67,68].…”

Section: Angiogenesis Assay Using the Cam Modelmentioning

confidence: 99%

The Effect of Surface-Modified Gold Nanorods on the Early Stage of Embryonic Development and Angiogenesis: Insight into the Molecular Pathways

Mahmoud

Zakaria

Kheraldine

et al. 2021

IJMS

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Gold nanorods have been implicated in several biomedical applications. Herein, the effect of two surface-modified gold nanorods on the early stages of embryogenesis and angiogenesis was investigated using avian embryos at three days and their chorioallantoic membrane (CAM) at five days of incubation. We found that gold nanorods (GNR) modified with PEGylated phospholipid moiety show a high mortality rate in embryos after four days of exposure compared to GNR modified with PEGylated cholesterol moiety. Meanwhile, our data revealed that surface modified-GNR significantly inhibit the formation of new blood vessels in the treated CAM model after 48 h of exposure. Moreover, we report that surface-modified GNR significantly deregulate the expression of several genes implicated in cell proliferation, invasion, apoptosis, cellular energy metabolism, and angiogenesis. On the other hand, our data point out that GNR treatments can modulate the expression patterns of JNK1/2/3, NF-KB/p38, and MAPK, which could be the main molecular pathways of the nanorods in our experimental models.

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Dasatinib and PD-L1 inhibitors provoke toxicity and inhibit angiogenesis in the embryo

Cited by 10 publications

References 51 publications

PD‐L1/p‐STAT3 promotes the progression of NSCLC cells by regulating TAM polarization

PD‐L1/p‐STAT3 promotes the progression of NSCLC cells by regulating TAM polarization

L’embryon de poule

The Effect of Surface-Modified Gold Nanorods on the Early Stage of Embryonic Development and Angiogenesis: Insight into the Molecular Pathways

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