Data describing child development at 6 years after maternal cancer diagnosis and treatment during pregnancy

Abstract

This manuscript is an accompanying resource of the original research article entitled “Child development at 6 years after maternal cancer diagnosis and treatment during pregnancy” and present data that compare the outcome of 6-year-old-children born to women diagnosed with cancer during pregnancy (with or without treatment during pregnancy) (study group) with children born after an uncomplicated pregnancy (control group). Oncological, obstetrical and neonatal data were collected. Neurodevelopment was examined by clinical evaluation and neuropsychological testing (including intelligence, attention and memory tests) and by general health and behavior questionnaires. Cardiac evaluation included electro- and echocardiography. Univariate analyses of covariance were used to investigate between-group differences. A subgroup analysis was performed in chemotherapy-exposed children versus controls and anthracycline-exposed versus controls. Additionally, the incidence of behaviour problems was compared to matched controls for children whose mothers died and for those with surviving mothers.

Long-Term Neurodevelopmental Outcome of Children after in Utero Exposure to Chemotherapy

“…A summary of the studies describing the type of maternal cancer and the chemotherapy schemes administered during pregnancy while evaluating the neurodevelopmental outcome of children in utero exposed to chemotherapy is demonstrated in Tables 1 and 2. [16] Acute leukemia (7) Non-Hodgkin's lymphoma (18) Hodgkin's lymphoma (14 Acute leukemia (14) Non-Hodgkin's lymphoma (25) Hodgkin's lymphoma (19) COPA (6 Breast cancer (26) Ovarian cancer (4) Hodgkin's lymphoma (4) Acute leukemia (1) [27] and Van Gerwen et al, 2020 [28] Breast cancer (69) Hematological malignancy (20) Cervical cancer 10Ovarian cancer (10) Brain cancer (4) Oral cavity and oropharyngeal cavity cancer 4Nasopharyngeal cancer (1) Gastric cancer 2Colon cancer 1Melanoma 2 Breast cancer and hematological cancer (e.g., acute leukemia, Hodgkin's lymphoma, non-Hodgkin's lymphoma) were the most frequently diagnosed malignancies during gestation [13][14][15][16][17][18][19][20][21][22][23][25][26][27][28][29]. Additionally, several cases of cervical, ovarian, brain and gastric cancer were also reported [13,14,[20][21][22]24,[26][27][28][29...…”

“…Additionally, several cases of cervical, ovarian, brain and gastric cancer were also reported [13,14,[20][21][22]24,[26][27][28][29]. Some studies focused on a single type of pregnancy-related cancer analyzing its treatment along with the maternal and the fetal outcomes [15][16][17][18][23][24][25], whereas other studies integrated data regarding multiple cancer types, as shown in Table 1 [13,14,[20][21][22][26][27][28][29]. Furthermore, various chemotherapy regimens were administered during the course of pregnancy, depending on the type of maternal cancer diagnosed; a combination of anthracycline-based regimens was most commonly used [13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28].…”

“…Some studies focused on a single type of pregnancy-related cancer analyzing its treatment along with the maternal and the fetal outcomes [15][16][17][18][23][24][25], whereas other studies integrated data regarding multiple cancer types, as shown in Table 1 [13,14,[20][21][22][26][27][28][29]. Furthermore, various chemotherapy regimens were administered during the course of pregnancy, depending on the type of maternal cancer diagnosed; a combination of anthracycline-based regimens was most commonly used [13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28]. Cyclophosphamide, 5-fluorouracil, taxanes, and platinum derivatives were also regularly administered [13][14][15][16][17][18][19][20][21][22][23][24][2...…”

“…Furthermore, various chemotherapy regimens were administered during the course of pregnancy, depending on the type of maternal cancer diagnosed; a combination of anthracycline-based regimens was most commonly used [13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28]. Cyclophosphamide, 5-fluorouracil, taxanes, and platinum derivatives were also regularly administered [13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28]. In the majority of the studies included in the review, the antineoplastic agents were administered in the second and third trimester of pregnancy [13,14,[20][21][22][23][24][25][26][27][28][29]; however, in all studies mainly investigating hematological malignancies, chemotherapy was administered in the first trimester as well [15]…”

“…Cyclophosphamide, 5-fluorouracil, taxanes, and platinum derivatives were also regularly administered [13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28]. In the majority of the studies included in the review, the antineoplastic agents were administered in the second and third trimester of pregnancy [13,14,[20][21][22][23][24][25][26][27][28][29]; however, in all studies mainly investigating hematological malignancies, chemotherapy was administered in the first trimester as well [15][16][17][18][19].…”