2023
DOI: 10.1038/s41467-023-43372-2
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Data-driven grading of acute graft-versus-host disease

Evren Bayraktar,
Theresa Graf,
Francis A. Ayuk
et al.

Abstract: Despite advances in allogeneic hematopoietic cell transplantation, acute graft-versus-host disease (aGVHD) remains its leading complication, yet with heterogeneous outcomes. Here, we analyzed aGVHD phenotypes and clinical classifications in depth in large, multicenter cohorts involving 3019 patients and addressed prevailing gaps by developing data-driven models. We compared, tested and verified these along with all conventional classifications in independent cohorts and found that data-driven grading outperfor… Show more

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