This paper focuses on the geology and geochemistry of the Rhyacian Josephine gold deposit in northwestern Ghana, where gold is primarily hosted in quartzites, with other lithologies observed, including granitoids, mafic intrusions, and gneisses. Four deformational events, D JO0 , D JO1 , D JO2 , and D JO3 , are observed. D JO0 is synonymous with the primary preserved sedimentary crossbedding in the quarzitic rocks. Gold mineralization within the deposit is mainly associated with the D JO1 NNW-trending dextral and steeply dipping sinusoidal shear zone. Gold occurs primarily as free gold and invisible gold within the lattices of the disseminated arsenopyrite along the shear foliation planes of the host rock. The ore body geometry is 15-40 m wide and strikes 800 m in the NNW direction. Silicification, sericitization, chloritization, and sulphidation are the main alteration assemblages associated with the gold mineralization zones within the Josephine deposit. Pathfinder elements for gold are stibnite, tellurium, sulphur, copper, silver, and Lead.