Engineer-to-Order (ETO) environments are gaining more and more popularity these days with customers demanding custom-designed products to meet their specific needs. ETO enterprises are often having to rely on the combined design capabilities of the entire value chain in order to satisfy customer requirements. Due to the increased level of interaction with customers and between partners in the value chain, it becomes imperative to have an effective means of communication and data storage. Information systems can be leveraged to streamline the communication process and improve data exchange between the members of the value chain. This chapter will examine how information systems can be the key enabler in ETO supply chain management and identify some of the issues involved. The chapter will conclude with suggestions on future direction for research in this area.