Data from Digital Health Devices Informs Ideal Cardiovascular Health

2021

JCM

Self Cite

Former smokers remain at increased risk for cardiovascular diseases compared to never smokers, but have lower risk than current smokers. We therefore hypothesized that former smokers would have an ideal cardiovascular health phenotype that was intermediate between current and never smokers. Differences in ideal cardiovascular health between never (n = 1025), former (n = 428), and current (n = 108) smokers were evaluated in the My Research Legacy study, which collected cardiovascular health data from the Life’s Simple 7 survey and digital health devices. Former smokers had a higher burden of prevalent cardiovascular disease, hypertension, diabetes mellitus, and hypercholesterolemia compared to current and never smokers (all p < 0.01). Former smokers’ Life’s Simple 7 Health Scores, a measure of ideal cardiovascular health, were intermediate between current and never smokers (4.9 ± 1.3 vs. 6.3 ± 1.5 vs. 7.0 ± 1.4, p < 0.01). As former smokers shared similarities with both current and never smokers, we performed a cluster analysis, which identified two phenogroups of former smokers. The phenogroups differed significantly across all 7 cardiovascular health and behavior categories (all p < 0.01). These findings suggest that former smokers are a heterogeneous group and increased attention to cardiovascular health factors and behaviors is warranted to achieve ideal cardiovascular health.

Section: Methodsmentioning

confidence: 99%

“…Uploaded data were de-identified and categorized as weight, fitness or routine data by Validic based on device-specific algorithms. De-identified data were transmitted to secure servers maintained by The Broad Institute (Cambridge, MA, USA) and REAN Cloud LLC (Herndon, VA, USA) [ 16 ].…”

Section: Methodsmentioning

confidence: 99%

Ideal Cardiovascular Health in Former Smokers

2021

JCM

Self Cite

“…The My Research Legacy study was a cross-sectional study that examined ideal cardiovascular health in samples from across the United States [24]. This was a direct-toparticipant study that was conducted entirely online and enrolled participants between November 2016 and October 2018.…”

Section: Study Cohortmentioning

confidence: 99%

“…Individuals who participated in the study signed informed consent online. Participants in the study selfreported demographic data, prior history of cardiovascular diseases, and cardiovascular disease risk factors and answered questions about health and lifestyle data in the Life's Simple 7 survey of ideal cardiovascular health [24].…”

Section: Study Cohortmentioning

confidence: 99%

“…The subgroup of participants who registered digital devices received a unique link to Validic (Validic Inc., Durham, NC, USA) to upload their digital health device data. The uploaded digital health device data were de-identified, sorted into weight, fitness, or routine data by Validic based on device-specific algorithms, and transmitted as JSON files to secure servers at The Broad Institute (Cambridge, MA, USA) and REAN Cloud LLC (Herndon, VA, USA) [24].…”

Section: Study Cohortmentioning

confidence: 99%

See 1 more Smart Citation

Obesity and Ideal Cardiovascular Health: Results from the My Research Legacy Study

2021

Obesities

Self Cite

Obesity is associated with increased risk for cardiovascular diseases compared to normal-weight and overweight status. We hypothesized that obese subjects would have lower ideal cardiovascular health than normal-weight and overweight subjects, but a subset among the obese would have a favorable cardiovascular health profile. Differences in ideal cardiovascular health between normal-weight (n = 523), overweight (n = 378), and obese (n = 660) subjects were examined using data from the Life’s Simple 7 survey and digital health devices. Obese participants were more likely to have prevalent cardiovascular disease, diabetes mellitus, hypertension, and hypercholesterolemia compared to normal weight and overweight (all p < 0.01). Life’s Simple 7 Health Scores, a measure of ideal cardiovascular health, were lower in obese than in normal-weight and overweight groups (5.6 ± 1.2 vs. 8.0 ± 1.1 vs. 6.8 ± 1.1, p < 0.01). A subset of obese with ideal cardiovascular health scores was identified (n = 103). Compared to obese with non-ideal health scores (n = 557), these individuals were more likely to have ideal cardiovascular risk factor status, diet, and exercise profiles. These findings indicate that there is heterogeneity among obese persons and suggest that an assessment of cardiovascular health factors and behaviors can identify areas for intervention beyond weight reduction alone to optimize cardiovascular health.

A precision medicine approach to sex-based differences in ideal cardiovascular health

2021

Sci Rep

Self Cite

Cardiovascular disease risk factor profiles and health behaviors are known to differ between women and men. Sex-based differences in ideal cardiovascular health were examined in the My Research Legacy study, which collected cardiovascular health and lifestyle data via Life’s Simple 7 survey and digital health devices. As the study overenrolled women (n = 1251) compared to men (n = 310), we hypothesized that heterogeneity among women would affect comparisons of ideal cardiovascular health. We identified 2 phenogroups of women in our study cohort by cluster analysis. The phenogroups differed significantly across all 7 cardiovascular health and behavior domains (all p < 0.01) with women in phenogroup 1 having a lower Life’s Simple 7 Health Score than those in phenogroup 2 (5.9 ± 1.3 vs. 7.6 ± 1.3, p < 0.01). Compared to men, women in phenogroup 1 had a higher burden of cardiovascular disease risk factors, exercised less, and had lower ideal cardiovascular health scores (p < 0.01). In contrast, women in phenogroup 2 had fewer cardiovascular risk factors but similar exercise habits and higher ideal cardiovascular health scores than men (p < 0.01). These findings suggest that heterogeneity among study participants should be examined when evaluating sex-based differences in ideal cardiovascular health.