Abstract:<div>AbstractPurpose:<p>Endometrioid endometrial cancer is strongly associated with obesity and insulin resistance. Metformin, an insulin sensitizer, reduces endometrial tumor growth <i>in vitro</i>. Presurgical window studies allow rapid <i>in vivo</i> assessment of antitumor activity. Previous window studies found metformin reduced endometrial cancer proliferation but these lacked methodological rigor. PREMIUM measured the anti-proliferative effect of metformin <i>in… Show more
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