This paper evaluates the ability of simplified superstructure models, including two shear frame models and a single-story model, in predicting global responses of a full-scale five-story steel moment-frame buildings isolated by triple friction pendulum bearings subjected to earthquake motions. The investigated responses include displacement of the isolation system, roof drift, story drift, and floor acceleration. Mechanical properties of the simplified superstructure models were derived from the modal information of a verified full 3-D model. The comparison between the analytical responses and experimental responses shows that the simplified models can well predict the displacement of the isolation system. Furthermore, the shear-frame models are adequate for predicting floor acceleration when the specimen is subjected to horizontal ground motions. However, when the specimen is subjected to 3-D motions, the shear-frame models un-conservatively predict floor acceleration. The full 3-D model improves the prediction of story drift compared with the simplified models for both horizontal and 3-D motions.