In the modern world, issues of personnel security management are getting more popular and significant in order to protect companies from internal and external threats. The article analyses modern approaches and models of personnel security management in the structure of economic security. The aim of the paper is to develop recommendations for the use of modern information systems and models of personnel security management for Ukrainian enterprises of strategic importance to the national economy. It is determined that the most general and broad approach to the definition of personnel security involves not only prevention of violations of the norms and principles of confidentiality of information by the personnel but also the organization of the security of the personnel itself, therefore, there is a need for the formation of an integrated system of personnel security management at the corporate level. The author's analysis of modern systems of personnel security management has shown the importance of researching the psychological and behavioural characteristics of employees not only in the corporate environment but also beyond its borders. It has been proved that the introduction of modern modelling techniques (in particular, the Bayesian model, the nonlinear model of the neural net with feedback, linear regression, k-mean algorithms, etc.) will contribute to the strengthening of the system in the practice of providing personal security under the influence of external and internal threats. It is recommended that domestic enterprises introduce a comprehensive and integrated personnel security system to improve the practice of psychological diagnosis and monitoring of employees' actions, in particular, improving the systems for collecting information on employee behavioural indicators in the corporate environment and beyond. The necessity of using the modern toolkit of the technical component of information security and certification system using the international standard ISO 27001 is proved, which significantly improves personnel security management in the structure of economic security of enterprises, reduces operational risk and increases the awareness of managers and ordinary employees. It is recommended to introduce improved technical systems in those types of activities and industries that are strategic for the economic growth of Ukraine's national economy and ensuring the country's defence and competitiveness.