This paper describes the design and proof of concept of a web-based e-business decision-making support system (EBDMSS), to deliver a balanced scorecard (BSC)-based modeling and analysis in support of e-business strategic management. EBDMSS is designed, built and validated through a conceptual design research method. Its design is theoretically underpinned in three DMSS design schemes: an e-business BSC (EBBSC) framework for decision-making process (DMP), a DMSS architecture, and a DMSS design-evaluation framework. The EBBSC scheme aims to support e-business managers during the business strategy making process in a comprehensive, integrated, and continuous manner. The DMSS architecture and the DMSS design-evaluation frameworks help to deliver the expected design capabilities of an integrated DMSS. The paper reports related literature review, conceptual design methodology and principles, EBDMSS design and prototype implementation, and illustrates how practitioners can use this system to deliver a valuable range of embodied e-business strategy expertise in support of real-time decision making. The paper concludes with limitations of design, implementation and validation, recommendations for further research, and conclusions.