Predictive Analytics, Soft Computing (SC) and Optimization, Data Mining and Data Science are rapidly becoming some of the most-discussed, perhaps utmost glorified topics in healthcare business. Artificial Intelligence, Machine Learning, Artificial Neural Networks, Fuzzy Logic, Expert Systems, etc., is well-studied disciplines with a long history of success in many industries. Healthcare can acquire treasured sessions from this prior achievement to startup the efficacy of predictive analytics for refining patient care, chronic disease management, hospital administration and supply chain efficiencies. The prospects that presently occurs for healthcare systems is to state what "predictive analytics" stands for to them and how can it be cast off furthermost excellently to cause further enhancements.In all industries including healthcare, prediction plays a best worthwhile role when that data is passed on as accomplishments. The inclinations to mediate the vital data is in harnessing the power of historical and real-time data with visions from forecasting those data based on the times ahead. Importantly, to best gauge efficacy and value, both the predictor and the intervention must be integrated within the same system and workflow where the trend occurs.A valuable report of the organized publicity and expectation of predictive analytics in healthcare through a blend of psychology, digital technology, and entrepreneurship is available for real-time implementation for the good of the public. Review and evaluation on these disciplines pave ways to open up new arenas envisaging the future trends of Predictive analytics, Data Mining and Science and Soft Computing (SC) in healthcare, stepping strongly into pervasive computing, ambient intelligence, ubiquitous computing and many more automated technical concepts and computing's ahead.