The article analyzes approaches to substantiating new high-quality solutions for businesses and territories based on the development of their business ecosystems. Business ecosystems are viewed as the interaction of individual stakeholders in the space of value formation including in territories or industries from manufacturing to retail in the domestic, national and international markets. The main goal of the work is to substantiate the possibilities for the integrated development of the region’s business ecosystems based on digital models of assessment and the formation of their product lines and integration into global supply chains. The main hypothesis is based on theoretical approaches and analysis of practice that modern businesses actively using digital technologies exhibit new network practices of interaction in the value space and in their integration with consumers, the community and government regulation form effective business ecosystems. The article was prepared within the framework of the Grant of the RFBR and the Government of the Krasnoyarsk Territory No. 20-410-242916 r_mk Krasnoyarsk.