2024
DOI: 10.1101/2024.05.29.595857
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Data-modeling the interplay between single cell shape, single cell protein expression, and tissue state

Yuval Tamir,
Yuval Bussi,
Claudia Owczarek
et al.

Abstract: Changes in cell shape are fundamentally involved in signaling, intracellular organization, function, and intercellular interactions within tissues, in health and disease. Investigating the interplay between cell shape and protein expression was limited, until recently, by the number of proteins that can be imaged simultaneously or by population averaging. We combined spatial multiplexed single cell imaging and machine learning to systematically investigate the intricate relationships between cell shape and pro… Show more

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