Data on a simple method for producing a solution that contains a high partial pressure of oxygen and a low partial pressure of carbon dioxide

Abstract

The data presented here shows a simple method for producing a solution that contains a high partial pressure of oxygen (pO2) and a low partial pressure of carbon dioxide (pCO2). This novel solution was created by simply injecting oxygen gas into conventional supplemental bicarbonate fluid for renal replacement therapy. We compared the gas profiles of the novel solution and the conventional fluid in vitro. There was a significant increase in pO2 and pH, and a significant decrease in pCO2 in the experimental solution, in each of which an additional volume of oxygen was injected. The method shown here is capable of facilitating an increase of pO2 and decrease of pCO2 by using a closed fluid bag without any special devices.

Oxygen delivery to the blood stream by the dialysis fluid during continuous renal replacement therapy ex vivo

“…We developed a solution saturated with dissolved oxygen using a simple method, and observed increases in the pO 2 and total oxygen content (CaO 2 ) in the blood in vitro using this solution [7]. Applying this method to the supplemental bicarbonate dialysis fluid, a significant increase in the pO 2 and simultaneous decrease in the partial pressure of carbon dioxide (pCO 2 ) were observed [8]. Gehlbach et al suggested that an intravenous (IV) supersaturated solution might also improve hypoxia in critically ill patients with respiratory failure [9].…”