Data on characterization of glass biochips and validation of the label-free biosensor for detection of autoantibodies in human serum

Pushkarev, A.V.; Орлов, А. В.; Znoyko, S.L.; Novichikhin, D.O.; Bragina, V.A.; Sizikov, Artem A.; Alipour, E.; Ghourchian, Hedayatollah; Nikitin, A.I.; Sorokin, G. M.; Gorshkov, B. G.; Никитин, П. И.

doi:10.1016/j.dib.2020.105648

Cited by 4 publications

(1 citation statement)

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“…The developed method for characterizing the activity of autoantibodies by registering the kinetics of their binding to free native antigens is based on the polyvalence of autoantibodies. The proposed biosensor and the method of native kinetic registration can be used to develop new criteria for the complex diagnosis of autoimmune diseases, based not only on traditional concentration measurements but also on the quantitative assessment of the aggressiveness of autoantibodies [107,108].…”

Section: Detection Of Diagnostic Antibodiesmentioning

confidence: 99%

Antibodies as Biosensors’ Key Components: State-of-the-Art in Russia 2020–2021

Rudenko

Fursova

Shepelyakovskaya

et al. 2021

Sensors

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The recognition of biomolecules is crucial in key areas such as the timely diagnosis of somatic and infectious diseases, food quality control, and environmental monitoring. This determines the need to develop highly sensitive display devices based on the achievements of modern science and technology, characterized by high selectivity, high speed, low cost, availability, and small size. Such requirements are met by biosensor systems—devices for reagent-free analysis of compounds that consist of a biologically sensitive element (receptor), a transducer, and a working solution. The diversity of biological material and methods for its immobilization on the surface or in the volume of the transducer and the use of nanotechnologies have led to the appearance of an avalanche-like number of different biosensors, which, depending on the type of biologically sensitive element, can be divided into three groups: enzyme, affinity, and cellular/tissue. Affinity biosensors are one of the rapidly developing areas in immunoassay, where the key point is to register the formation of an antigen–antibody complex. This review analyzes the latest work by Russian researchers concerning the production of molecules used in various immunoassay formats as well as new fundamental scientific data obtained as a result of their use.

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Section: Detection Of Diagnostic Antibodiesmentioning

confidence: 99%