Data on effect of Tempeh Fermentation on patients with type II diabetes

Su, Hui‐Kan; Tsai, Ming‐Hsien; Chao, How‐Ran; Wu, Mei‐Li; Lu, Jian‐He

doi:10.1016/j.dib.2021.107310

Cited by 5 publications

(6 citation statements)

References 5 publications

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“…Tempeh also reduces insulin resistance, HbA1c, and serum glucose levels in streptozotocin combined with high-fat diet-induced T2D rats (Huang et al, 2018). Additionally, our previous results suggested that consuming 2 g of tempeh daily for a period of 3 months attenuated HbA1C and triglyceride levels in participants (Su et al, 2021). These findings suggest that tempeh ameliorates hyperglycemia, hyperlipidemia, and hyperinsulinemia.…”

Section: Accepted Manuscriptmentioning

confidence: 73%

“…The previous study indicated that the nematodes of C. elegans share several fundamental physiological and stress response processes with their homologues in most human genes (60%-80%), including multiple signal transduction pathways (Kaletta and Hengartner, 2006b). Additionally, our previous clinical study also suggested that tempeh attenuated HbA1C and triglyceride levels in participants (Su et al, 2021). Therefore,…”

Section: Accepted Manuscriptmentioning

confidence: 87%

“…The results of our previous clinical study showed that tempeh attenuates HbA1C and triglyceride levels in participants (Su et al, 2021). Therefore, we next investigated whether tempeh would have any effect on worms exposed to TRAP PM2.5 and fed high glucose.…”

Section: Accepted Manuscript 33 Tempeh Extract Pretreatment Ameliorat...mentioning

confidence: 97%

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Traffic-related-air-pollutant PM2.5 Caused Toxicity on Caenorhabditis elegans with Cotreatment of High-dose Glucose and Tempeh

Tsai

Huang

et al. 2023

Aerosol Air Qual. Res.

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Rapid economic development and urbanization have significantly increased PM2.5-induced and hyperglycemia-induced toxicological effects. Tempeh is a traditional Indonesian food and may be beneficial for patients with type II diabetes. However, the toxicological effects of co-exposure to traffic-related-airpollutant (TRAP) PM2.5 with high glucose and the potential therapeutic effect of tempeh remain unclear.Using Caenorhabditis elegans (C. elegans) as an in vivo animal model, we found that exposure to 12.74 mg L -1 TRAP PM2.5 and 80 mM D-glucose could induce toxicity in nematodes that affects growth, reproduction, locomotion behavior, and lifespan. Moreover, TRAP PM2.5 and high glucose diet co-treatment reinforced these adverse effects on C. elegans. However, pretreatment with 200 µg of tempeh extract had the greatest improvement in the adverse effects of treatment with or without 12.74 mg L -1 TRAP PM2.5 and with or without 80 mM D-glucose on C. elegans. In addition, tempeh treatment also ameliorated the altered mRNA expression of the antioxidant gene in C. elegans treated with or without TRAP PM2.5 and with or without high-dose glucose diets. These findings reveal that co-exposure to TRAP PM2.5 and high-dose glucose causes more serious health effects, while tempeh could modulate oxidative stress which ameliorated TRAP PM2.5-induced and hyperglycemia-induced toxicological effects.

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Section: Accepted Manuscriptmentioning

confidence: 73%

Section: Accepted Manuscriptmentioning

confidence: 87%

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Traffic-related-air-pollutant PM2.5 Caused Toxicity on Caenorhabditis elegans with Cotreatment of High-dose Glucose and Tempeh

Tsai

Huang

et al. 2023

Aerosol Air Qual. Res.

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“…In the United States, the nutritional content per 84 g of commercial Tempeh includes 14.5 ± 2.4 g protein, 7.0 ± 4.6 g fiber, 0.6 ± 0.7 g saturated fat, 0.8 ± 1.3 g sugar, 14.2 ± 6.3 g carbohydrate, 152.5 ± 15.9 cal energy, 64.4 ± 22.3 mg calcium, 153.8 ± 151.2 mg potassium, 0.8 ± 1.1 g monounsaturated fatty acids, and 1.2 ± 1.6 g polyunsaturated fatty acids, all being free of cholesterol as well as trans fatty acids (Ahnan‐Winarno et al, 2021 ). Our previous clinical study results suggested that 2‐g Tempeh daily for a period of 3 months attenuated HbA1c and triglyceride levels in participants (Su et al, 2021 ). One animal study suggested that a high‐grade protein and fiber diet could remodel the gut microbiota, resulting in improved glycemic control and ameliorated diabetes (Ni et al, 2022 ).…”

Section: Resultsmentioning

confidence: 94%

The effects of using Tempeh as a supplement for type 2 diabetes

Chen

et al. 2023

Food Science & Nutrition

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Studies suggest that the consumption of Tempeh can improve abnormal blood glucose and lipid parameters, although it remains still unclear as to whether Tempeh can improve tissue damage. In our study, db/db obese diabetic mice were given Tempeh 1 (300 mg/kg) and Tempeh 2 (600 mg/kg) for 3 months. The tissue samples collected were stained using different tissue‐staining methodologies and were compared with the diabetic control group that was not given any Tempeh. Our results demonstrated that consuming high‐dose Tempeh for 1 month could significantly reduce serum glucose and body weight in mice whereas the tissue section of our result could validate that consuming high‐dose Tempeh for 3 months effectively improves lipid droplet size and lipid accumulation in the liver, aorta, and kidney of the mice. Moreover, an indication of the recovery of the damaged tissue could be observed in the heart and pancreatic tissue when high dosage of Tempeh was given as a treatment. Thus, it can be concluded that continuous consumption of Tempeh as a treatment could improve both blood glucose and body weight of diabetic mice while also improving lipid accumulation and tissue damage.

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“…A prospective open‐label trial showed that tempeh consumption improves glycemic control and triglyceride levels 123 .…”

Section: Potential Beneficial Effect Of Fermented Soybean Foods On Di...mentioning

confidence: 99%

Fermented soybean foods and diabetes

Hashimoto,

Hamaguchi,

Fukui

2023

J of Diabetes Invest

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The number of patients with type 2 diabetes mellitus is increasing, and its prevention and management are important. One of the factors contributing to the increased incidence of type 2 diabetes mellitus is the change in dietary habits, including a Westernized diet. Fermented foods are foods that are transformed by the action of microorganisms to produce beneficial effects in humans and have been consumed for thousands of years. The production and consumption of fermented soy foods, including natto, miso, douchi, cheonggukjang, doenjang, tempeh, and fermented soy milk, are widespread in Asian countries. This review focuses on fermented soybean foods and summarizes their effects on diabetes. Fermentation increases the content of ingredients originally contained in soybeans and adds new ingredients that are not present in the original soybeans. Recent studies have revealed that fermented soybean food modifies the gut microbiota‐related metabolites by modifying dysbiosis. Furthermore, it has been reported that fermented soybean foods have antioxidant, anti‐inflammatory, and anti‐diabetic effects. In recent years, fermented foods, including fermented soybeans, have shown various beneficial effects. Therefore, it is necessary to continue focusing on the benefits and mechanisms of action of fermented foods.

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Data on effect of Tempeh Fermentation on patients with type II diabetes

Cited by 5 publications

References 5 publications

Traffic-related-air-pollutant PM2.5 Caused Toxicity on Caenorhabditis elegans with Cotreatment of High-dose Glucose and Tempeh

Traffic-related-air-pollutant PM2.5 Caused Toxicity on Caenorhabditis elegans with Cotreatment of High-dose Glucose and Tempeh

The effects of using Tempeh as a supplement for type 2 diabetes

Fermented soybean foods and diabetes

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