2017
DOI: 10.1016/j.dib.2017.10.061
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Data on the expression of PEPCK in HepG2 hepatocytes transfected with miR-195

Abstract: Dietary fats rich in saturated fatty acid (SFA) increase the risk of metabolic diseases, and certain microRNAs (miRNAs) dysregulated by SFA are associated with the pathogenesis of insulin resistance and type 2 diabetes. A previous study found that miR-195 is increased by SFA and impairs hepatic insulin signaling through the suppression of INSR (Yang et al., 2014) [1]. This article reports accompanying data to determine the effect of miR-195 on the expression of PEPCK, a key player in hepatic gluconeogenesis. T… Show more

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Cited by 6 publications
(3 citation statements)
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“…Due to the limited availability of human primary hepatocytes, HepG2 cells have extensively been used to study hepatic insulin signaling, as they appear to be closer to the in vivo situation despite their tumorigenic origin and show specific hepatocyte morphological characteristics. Sefried et al have shown an increase in insulin-mediated Akt phosphorylation [ 23 ] in HepG2 cells, and these findings are consistent with a reduction of PEPCK expression observed by Won-Mo Yang [ 24 ]. In parallel, several polyphenols, such as resveratrol and morin, improve glucose metabolism in these cells [ 25 , 26 ].…”
Section: Introductionsupporting
confidence: 78%
“…Due to the limited availability of human primary hepatocytes, HepG2 cells have extensively been used to study hepatic insulin signaling, as they appear to be closer to the in vivo situation despite their tumorigenic origin and show specific hepatocyte morphological characteristics. Sefried et al have shown an increase in insulin-mediated Akt phosphorylation [ 23 ] in HepG2 cells, and these findings are consistent with a reduction of PEPCK expression observed by Won-Mo Yang [ 24 ]. In parallel, several polyphenols, such as resveratrol and morin, improve glucose metabolism in these cells [ 25 , 26 ].…”
Section: Introductionsupporting
confidence: 78%
“…miR‐195‐5p, functioning as a diagnostic test, may contribute beneficially to both patients and physicians. Compared to traditional oral glucose tolerance tests, 15 serum may function as an adjuvant diagnostic method for GDM Yang et al observed that miR‐195 is increased by saturated fatty acids, which aimed to impair insulin signaling and glycogen metabolism in HepG2 cells and increased the risk of metabolic diseases 16,17 . A previous study also implied the potential diagnostic value of miR‐195‐5p in the diabetes model or related diseases.…”
Section: Discussionmentioning
confidence: 99%
“…The function of miR-195 has already been investigated in several distinct cancer types, such as non-small cell lung cancer [47], bladder cancer [48], breast cancer [49] and HCC [50]. To date, 17 genes, including PCMT1, SRC-3, CCND1, CCNE1, CDC25A, CCND3, CDK4, CDK6, E2F3, BTRC, IKKα, TAB3, VEGF, VAV2, CDC42, LATS2 and BCL-w, have been identified as targets of miR-195 in HCC [51][52][53][54]. miR-195 has also been implicated in various biological processes of HCC, including cell cycle, proliferation, apoptosis, drug resistance angiogenesis and metastasis [50].…”
Section: Hepg2 Huh7mentioning
confidence: 99%