Cloud computing is a virtualized, scalable, ubiquitous, and distributed computing paradigm that provides resources and services dynamically in a subscription based environment. Cloud computing provides services through Cloud Service Providers (CSPs). Cloud computing is mainly used for delivering solutions to a large number of business and scientific applications. Large-scale scientific applications are evaluated through cloud computing in the form of scientific workflows. Scientific workflows are dataintensive applications, and a single scientific workflow may be comprised of thousands of tasks. Deadline constraints, task failures, budget constraints, improper organization and management of tasks can cause inconvenience in executing scientific workflows. Therefore, we proposed a fault-tolerant and data-oriented scientific workflow management and scheduling system (FD-SWMS) in cloud computing. The proposed strategy applies a multi-criteria-based approach to schedule and manage the tasks of scientific workflows. The proposed strategy considers the special characteristics of tasks in scientific workflows, i.e., the scientific workflow tasks are executed simultaneously in parallel, in pipelined, aggregated to form a single task, and distributed to create multiple tasks. The proposed strategy schedules the tasks based on the data-intensiveness, provides a fault tolerant technique through a cluster-based approach, and makes it energy efficient through a load sharing mechanism. In order to find the effectiveness of the proposed strategy, the simulations are carried out on WorkflowSim for Montage and CyberShake workflows. The proposed FD-SWMS strategy performs better as compared with the existing state-of-the-art strategies. The proposed strategy on average reduced execution time by 25%, 17%, 22%, and 16%, minimized the execution cost by 24%, 17%, 21%, and 16%, and decreased the energy consumption by 21%, 17%, 20%, and 16%, as compared with existing QFWMS, EDS-DC, CFD, and BDCWS strategies, respectively for Montage scientific workflow. Similarly, the proposed strategy on average reduced execution time by 48%, 17%, 25%, and 42%, minimized the execution cost by 45%, 11%, 16%, and 38%, and decreased the energy consumption by 27%, 25%, 32%, and 20%, as compared with existing QFWMS, EDS-DC, CFD, and BDCWS strategies, respectively for CyberShake scientific workflow.