Background: It is significant for doctors and body area networks (BANs) to predict ECG signals accurately. At present, the prediction accuracy of many existing ECG prediction methods is generally low. In order to improve the prediction accuracy of ECG signals in BANs, a hybrid prediction method of ECG signals is proposed in this paper. Methods: The proposed prediction method combines variational mode decomposition (VMD), phase space reconstruction (PSR), and a radial basis function (RBF) neural network. First, the embedding dimension and delay time of PSR are calculated according to the trained set of ECG data. Second, the ECG data are decomposed into several intrinsic mode functions (IMFs). Third, the phase space of each IMF is reconstructed according to the embedding dimension and the delay time. Fourth, an RBF neural network is established and each IMF is predicted by the network. Finally, the prediction results of all IMFs are added to realize the final prediction result. Results: To evaluate the prediction performance of the proposed method, simulation experiments are carried out on ECG data from the MIT-BIH Arrhythmia Database. The experimental results show that the prediction index RMSE (root mean square error) of the proposed method is only 10-3 magnitude and that of some traditional prediction methods is 10-2 magnitude.Conclusions: Compared with some traditional prediction methods, the proposed method improves the prediction accuracy of ECG signals obviously.